Micro/nanofabricated environments for synthetic biology

C. Patrick Collier; Michael L. Simpson

doi:10.1016/j.copbio.2011.05.002

Micro/nanofabricated environments for synthetic biology

C. Patrick Collier, Michael L. Simpson

Nanofabrication Research Laboratory

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

A better understanding of how confinement, crowding and reduced dimensionality modulate reactivity and reaction dynamics will aid in the rational and systematic discovery of functionality in complex biological systems. Artificial microfabricated and nanofabricated structures have helped elucidate the effects of nanoscale spatial confinement and segregation on biological behavior, particularly when integrated with microfluidics, through precise control in both space and time of diffusible signals and binding interactions. Examples of nanostructured interfaces for synthetic biology include the development of cell-like compartments for encapsulating biochemical reactions, nanostructured environments for fundamental studies of diffusion, molecular transport and biochemical reaction kinetics, and regulation of biomolecular interactions as functions of microfabricated and nanofabricated topological constraints.

Original language	English
Pages (from-to)	516-526
Number of pages	11
Journal	Current Opinion in Biotechnology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.copbio.2011.05.002
State	Published - Aug 2011

Funding

We acknowledge support from the Center for Nanophase Materials Sciences, which is sponsored at Oak Ridge National Laboratory by the Scientific User Facilities Division, Office of Basic Energy Sciences, US Department of Energy. We thank Scott Retterer of the Center for Nanophase Materials Sciences for contributions to the manuscript.

Funders	Funder number
Center for Nanophase Materials Sciences
Scientific User Facilities Division
U.S. Department of Energy
Basic Energy Sciences
Oak Ridge National Laboratory

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10.1016/j.copbio.2011.05.002

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Micro/nanofabricated environments for synthetic biology

Abstract

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