Microfluidics-to-mass spectrometry: A review of coupling methods and applications

Xue Wang; Lian Yi; Nikita Mukhitov; Adrian M. Schrell; Raghuram Dhumpa; Michael G. Roper

doi:10.1016/j.chroma.2014.10.039

Microfluidics-to-mass spectrometry: A review of coupling methods and applications

Xue Wang, Lian Yi, Nikita Mukhitov, Adrian M. Schrell, Raghuram Dhumpa, Michael G. Roper

Research output: Contribution to journal › Review article › peer-review

105 Scopus citations

Abstract

Microfluidic devices offer great advantages in integrating sample processes, minimizing sample and reagent volumes, and increasing analysis speed, while mass spectrometry detection provides high information content, is sensitive, and can be used in quantitative analyses. The coupling of microfluidic devices to mass spectrometers is becoming more common with the strengths of both systems being combined to analyze precious and complex samples. This review summarizes select achievements published between 2010 and July 2014 in novel coupling between microfluidic devices and mass spectrometers. The review is subdivided by the types of ionization sources employed, and the different microfluidic systems used.

Original language	English
Pages (from-to)	98-116
Number of pages	19
Journal	Journal of Chromatography A
Volume	1382
DOIs	https://doi.org/10.1016/j.chroma.2014.10.039
State	Published - Feb 20 2015
Externally published	Yes

Funding

This work was supported by a grant from the National Institutes of Health ( R01 DK080714 ).

Funders	Funder number
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases	R01DK080714

Keywords

Bioanalysis
Integrated devices
Lab-on-a-chip
Metabolomics
Proteomics

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10.1016/j.chroma.2014.10.039

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AU - Schrell, Adrian M.

AU - Dhumpa, Raghuram

AU - Roper, Michael G.

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KW - Lab-on-a-chip

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Microfluidics-to-mass spectrometry: A review of coupling methods and applications

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Keywords

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