@inproceedings{b37ddad816044fd8aa1f5b17647d8938,
title = "MICROFLUIDIC PEN FOR LONG-TERM LOCAL DELIVERY THROUGH TISSUE WITH MITIGATION OF LATERAL DIFFUSION",
abstract = "Spatiotemporal responses in biological tissues are critical drivers of health. Local stimulation of ex vivo tissue samples can facilitate the evaluation of such responses, but current local delivery technology is limited to surface applications, mechanical invasiveness, or short delivery time due to reagent diffusion. These limitations make it challenging to stimulate and observe regional responses in ex vivo cultures over long periods. For this reason, we developed a user-friendly, rapidly fabricated microfluidic pen that can locally deliver substances through a thick substrate for extended time periods (32 min) while mitigating lateral diffusion of the delivered species.",
keywords = "3D printing, cell culture, local delivery, microfluidic probe, sheath flow, tissue stimulation",
author = "Hannah Musgrove and Pompano, {Rebecca R.}",
note = "Publisher Copyright: {\textcopyright} 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2022 ; Conference date: 23-10-2022 Through 27-10-2022",
year = "2022",
language = "English",
series = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "961--962",
booktitle = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}