Microcantilever biosensors

R. Datar; A. Passian; R. Desikan; T. Thundat

doi:10.1109/ICSENS.2007.4388320

Microcantilever biosensors

R. Datar
, A. Passian
, R. Desikan
, T. Thundat

Quantum Sensing and Computing

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Scopus citations

Abstract

Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.

Original language	English
Title of host publication	The 6th IEEE Conference on SENSORS, IEEE SENSORS 2007
Pages	5
Number of pages	1
DOIs	https://doi.org/10.1109/ICSENS.2007.4388320
State	Published - 2007
Event	6th IEEE Conference on SENSORS, IEEE SENSORS 2007 - Atlanta, GA, United States Duration: Oct 28 2007 → Oct 31 2007

Publication series

Name	Proceedings of IEEE Sensors

Conference

Conference	6th IEEE Conference on SENSORS, IEEE SENSORS 2007
Country/Territory	United States
City	Atlanta, GA
Period	10/28/07 → 10/31/07

Funding

We acknowledge the help received from Drs. Sangmin Jeon, Arun Majumdar, Karen Stevenson, and Guanghua Wu. K.M.H. acknowledges support from Oak Ridge Associated Universities. Research sponsored by the Office of Biological and Environmental Research (OBER), U.S. DOE. Oak Ridge National Laboratory (ORNL) is managed by UT-Battelle, LLC for the U.S. Department of Energy under Contract No. DE-AC05-00OR22725.

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10.1109/ICSENS.2007.4388320

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title = "Microcantilever biosensors",

abstract = "Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.",

author = "R. Datar and A. Passian and R. Desikan and T. Thundat",

year = "2007",

doi = "10.1109/ICSENS.2007.4388320",

language = "English",

isbn = "1424412617",

series = "Proceedings of IEEE Sensors",

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T1 - Microcantilever biosensors

AU - Datar, R.

AU - Passian, A.

AU - Desikan, R.

AU - Thundat, T.

PY - 2007

Y1 - 2007

N2 - Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.

AB - Microcantilever arrays have been used for multiplexed, label-free detection of biomolecules. Adsorption of analyte molecules on immobilized receptors on the cantilevers result in cantilever bending due to surface free energy variation. Piezoresistive readout of cantilever bending offers a simple method of signal transduction that is compatible with microfabrication. Although the microcantilever-based biosensing appears to high sensitivity and selectivity, reproducibility of the technique appears to be a challenge. We have developed a novel method of immobilizing receptors that increases the reproducibility. We have demonstrated simultaneous detection of cancer and cardiac markers using cantilever arrays with immobilized receptors.

UR - https://www.scopus.com/pages/publications/48349109342

U2 - 10.1109/ICSENS.2007.4388320

DO - 10.1109/ICSENS.2007.4388320

M3 - Conference contribution

AN - SCOPUS:48349109342

SN - 1424412617

SN - 9781424412617

T3 - Proceedings of IEEE Sensors

SP - 5

BT - The 6th IEEE Conference on SENSORS, IEEE SENSORS 2007

T2 - 6th IEEE Conference on SENSORS, IEEE SENSORS 2007

Y2 - 28 October 2007 through 31 October 2007

ER -

Microcantilever biosensors

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