Metaproteomics: Harnessing the power of high performance mass spectrometry to identify the suite of proteins that control metabolic activities in microbial communities

Robert L. Hettich, Chongle Pan, Karuna Chourey, Richard J. Giannone

Research output: Contribution to journalArticlepeer-review

144 Scopus citations

Abstract

The availability of extensive genome information for many different microbes, including unculturable species in mixed communities from environmental samples, has enabled systems-biology interrogation by providing a means to access genomic, transcriptomic, and proteomic information. To this end, metaproteomics exploits the power of high-performance mass spectrometry for extensive characterization of the complete suite of proteins expressed by a microbial community in an environmental sample.

Original languageEnglish
Pages (from-to)4203-4214
Number of pages12
JournalAnalytical Chemistry
Volume85
Issue number9
DOIs
StatePublished - May 7 2013

Funding

FundersFunder number
National Institute of Diabetes and Digestive and Kidney DiseasesUH2DK083991

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