Metallo-Helicoid with Double Rims: Polymerization Followed by Folding by Intramolecular Coordination

Guang Qiang Yin; Sneha Kandapal; Chung Hao Liu; Heng Wang; Jianxiang Huang; Shu Ting Jiang; Tan Ji; Yu Yan; Sandra Khalife; Ruhong Zhou; Libin Ye; Bingqian Xu; Hai Bo Yang; Mu Ping Nieh; Xiaopeng Li

doi:10.1002/anie.202010696

Metallo-Helicoid with Double Rims: Polymerization Followed by Folding by Intramolecular Coordination

Guang Qiang Yin, Sneha Kandapal, Chung Hao Liu, Heng Wang, Jianxiang Huang, Shu Ting Jiang, Tan Ji, Yu Yan, Sandra Khalife, Ruhong Zhou, Libin Ye, Bingqian Xu, Hai Bo Yang, Mu Ping Nieh, Xiaopeng Li

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

In this study, we established a feasible strategy to construct a new type of metallo-polymer with helicoidal structure through the combination of covalent polymerization and intramolecular coordination-driven self-assembly. In the design, a tetratopic monomer (M) was prepared with two terminal alkynes in the outer rim for polymerization, and two terpyridines (TPYs) in the inner rim for subsequent folding by selective intramolecular coordination. Then, the linear covalent polymer (P) was synthesized by polymerization of M via Glaser-Hay homocoupling reaction. Finally, intramolecular coordination interactions between TPYs and Zn(II) folded the backbone of P into a right- or left-handed metallo-helicoid (H) with double rims. Owing to multiple positive charges on the inner rim of helicoid, double-stranded DNA molecules (dsDNA) could interact with H through electrostatic interactions. Remarkably, dsDNA allowed exclusive formation of H with right handedness by means of chiral induction.

Original language	English
Pages (from-to)	1281-1289
Number of pages	9
Journal	Angewandte Chemie - International Edition
Volume	60
Issue number	3
DOIs	https://doi.org/10.1002/anie.202010696
State	Published - Jan 18 2021
Externally published	Yes

Funding

The authors acknowledge the support from Shenzhen University and University of South Florida. X.L. also acknowledges the support from Tencent Founders Alumni Foundation.

Funders	Funder number
Tencent Founders Alumni Foundation
University of South Florida
Shenzhen University

Keywords

coordination-driven self-assembly
helicoid
metallo-polymers
terpyridine
tetraphenylethylene

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10.1002/anie.202010696

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Yin, G. Q., Kandapal, S., Liu, C. H., Wang, H., Huang, J., Jiang, S. T., Ji, T., Yan, Y., Khalife, S., Zhou, R., Ye, L., Xu, B., Yang, H. B., Nieh, M. P., & Li, X. (2021). Metallo-Helicoid with Double Rims: Polymerization Followed by Folding by Intramolecular Coordination. Angewandte Chemie - International Edition, 60(3), 1281-1289. https://doi.org/10.1002/anie.202010696

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abstract = "In this study, we established a feasible strategy to construct a new type of metallo-polymer with helicoidal structure through the combination of covalent polymerization and intramolecular coordination-driven self-assembly. In the design, a tetratopic monomer (M) was prepared with two terminal alkynes in the outer rim for polymerization, and two terpyridines (TPYs) in the inner rim for subsequent folding by selective intramolecular coordination. Then, the linear covalent polymer (P) was synthesized by polymerization of M via Glaser-Hay homocoupling reaction. Finally, intramolecular coordination interactions between TPYs and Zn(II) folded the backbone of P into a right- or left-handed metallo-helicoid (H) with double rims. Owing to multiple positive charges on the inner rim of helicoid, double-stranded DNA molecules (dsDNA) could interact with H through electrostatic interactions. Remarkably, dsDNA allowed exclusive formation of H with right handedness by means of chiral induction.",

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AU - Yin, Guang Qiang

AU - Kandapal, Sneha

AU - Liu, Chung Hao

AU - Wang, Heng

AU - Huang, Jianxiang

AU - Jiang, Shu Ting

AU - Ji, Tan

AU - Yan, Yu

AU - Khalife, Sandra

AU - Zhou, Ruhong

AU - Ye, Libin

AU - Xu, Bingqian

AU - Yang, Hai Bo

AU - Nieh, Mu Ping

AU - Li, Xiaopeng

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N2 - In this study, we established a feasible strategy to construct a new type of metallo-polymer with helicoidal structure through the combination of covalent polymerization and intramolecular coordination-driven self-assembly. In the design, a tetratopic monomer (M) was prepared with two terminal alkynes in the outer rim for polymerization, and two terpyridines (TPYs) in the inner rim for subsequent folding by selective intramolecular coordination. Then, the linear covalent polymer (P) was synthesized by polymerization of M via Glaser-Hay homocoupling reaction. Finally, intramolecular coordination interactions between TPYs and Zn(II) folded the backbone of P into a right- or left-handed metallo-helicoid (H) with double rims. Owing to multiple positive charges on the inner rim of helicoid, double-stranded DNA molecules (dsDNA) could interact with H through electrostatic interactions. Remarkably, dsDNA allowed exclusive formation of H with right handedness by means of chiral induction.

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Metallo-Helicoid with Double Rims: Polymerization Followed by Folding by Intramolecular Coordination

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