Metabolic differences in microbial cell populations revealed by nanophotonic ionization

Bennett N. Walker, Cory Antonakos, Scott T. Retterer, Akos Vertes

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Playing (yeast) laser tag: Laser desorption ionization mass spectrometry (LDI-MS) with nanopost arrays (NAPA, see scheme) was shown to quantitatively analyze trace amounts of intracellular metabolites from single cells of Saccharomyces cerevisiae (baker's yeast). The upregulation and downregulation of metabolites because of external stress (such as oxidative stress) are also observed, even at the single-cell level.

Original languageEnglish
Pages (from-to)3650-3653
Number of pages4
JournalAngewandte Chemie - International Edition
Volume52
Issue number13
DOIs
StatePublished - Mar 25 2013

Keywords

  • cellular differences
  • mass spectrometry
  • metabolites
  • nanostructures
  • single-cell analysis

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