Mesostructured TiO2 Gated Periodic Mesoporous Organosilica-Based Nanotablets for Multistimuli-responsive Drug Release

Tao Wang; Buyuan Guan; Xue Wang; Xiang Li; Ye Zhang; Zhen An Qiao; Yunling Liu; Qisheng Huo

doi:10.1002/smll.201501835

Mesostructured TiO₂ Gated Periodic Mesoporous Organosilica-Based Nanotablets for Multistimuli-responsive Drug Release

Tao Wang, Buyuan Guan, Xue Wang, Xiang Li, Ye Zhang, Zhen An Qiao, Yunling Liu, Qisheng Huo

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A multistimuli-responsive drug carrier is designed and successfully synthesized by self-assembly of thiol-modified periodic mesoporous organosilica (PMO) nanoparticles, coated gold nanoparticles (AuNPs), and mesostructured titanium dioxide (TiO₂). Dye-loaded PMO-Au@TiO₂ nanotablets are shown to respond to environmental changes (pH, temperature, and light) to achieve controlled release.

Original language	English
Pages (from-to)	5907-5911
Number of pages	5
Journal	Small
Volume	11
Issue number	44
DOIs	https://doi.org/10.1002/smll.201501835
State	Published - Nov 25 2015
Externally published	Yes

Funding

This work was supported by the National Natural Science Foundation of China (Grant Nos. 21171064, 21371067 and 21373095).

Keywords

drug delivery
mesoporous materials
organic-inorganic hybrid materials
self-assembly

Access to Document

10.1002/smll.201501835

Cite this

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title = "Mesostructured TiO2 Gated Periodic Mesoporous Organosilica-Based Nanotablets for Multistimuli-responsive Drug Release",

abstract = "A multistimuli-responsive drug carrier is designed and successfully synthesized by self-assembly of thiol-modified periodic mesoporous organosilica (PMO) nanoparticles, coated gold nanoparticles (AuNPs), and mesostructured titanium dioxide (TiO2). Dye-loaded PMO-Au@TiO2 nanotablets are shown to respond to environmental changes (pH, temperature, and light) to achieve controlled release.",

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author = "Tao Wang and Buyuan Guan and Xue Wang and Xiang Li and Ye Zhang and Qiao, \{Zhen An\} and Yunling Liu and Qisheng Huo",

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AU - Guan, Buyuan

AU - Wang, Xue

AU - Li, Xiang

AU - Zhang, Ye

AU - Qiao, Zhen An

AU - Liu, Yunling

AU - Huo, Qisheng

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KW - drug delivery

KW - mesoporous materials

KW - organic-inorganic hybrid materials

KW - self-assembly

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