Measurement of cross sections for the 232Th(P,4n) 229Pa reaction at low proton energies

C. U. Jost; J. R. Griswold; S. H. Bruffey; S. Mirzadeh; D. W. Stracener; C. L. Williams

doi:10.1063/1.4802383

Measurement of cross sections for the ²³²Th(P,4n) ²²⁹Pa reaction at low proton energies

C. U. Jost, J. R. Griswold, S. H. Bruffey, S. Mirzadeh, D. W. Stracener, C. L. Williams

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

24 Scopus citations

Abstract

The alpha-emitters ²²⁵Ac and ²¹³Bi are of great interest for alpha-radioimmunotherapy which uses radioisotopes attached to cancer-seeking antibodies to efficiently treat various types of cancers. Both radioisotopes are daughters of the long-lived ²²⁹Th(t _1/2=7880y). ²²⁹Th can be produced by proton irradiation of ²³²Th and ²³⁰Th, either directly or through production of isobars that beta-decay into ²²⁹Th. To obtain excitation functions, ²³²Th and ²³⁰Th have been irradiated at the On-Line Test Facility at the Holifield Radioactive Ion Beam Facility at ORNL. Benchmark tests conducted with Cu and Ni foils show very good agreement with literature results. The experiments with thorium targets were focused on the production of ²²⁹Pa and its daughter ²²⁵Ac from both ²³²Th and ²³⁰Th. Differential cross-sections for production of ²²⁹Pa and other Pa isotopes have been obtained.

Original language	English
Title of host publication	Application of Accelerators in Research and Industry - Twenty-Second International Conference
Pages	520-524
Number of pages	5
DOIs	https://doi.org/10.1063/1.4802383
State	Published - 2013
Event	22nd International Conference on the Application of Accelerators in Research and Industry, CAARI 2012 - Fort Worth, TX, United States Duration: Aug 5 2012 → Aug 10 2012

Publication series

Name	AIP Conference Proceedings
Volume	1525
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	22nd International Conference on the Application of Accelerators in Research and Industry, CAARI 2012
Country/Territory	United States
City	Fort Worth, TX
Period	08/5/12 → 08/10/12

Keywords

Accelerator
Medical isotopes
Thorium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1063/1.4802383

Cite this

Jost, C. U., Griswold, J. R., Bruffey, S. H., Mirzadeh, S., Stracener, D. W., & Williams, C. L. (2013). Measurement of cross sections for the ²³²Th(P,4n) ²²⁹Pa reaction at low proton energies. In Application of Accelerators in Research and Industry - Twenty-Second International Conference (pp. 520-524). (AIP Conference Proceedings; Vol. 1525). https://doi.org/10.1063/1.4802383

@inproceedings{bce652a9f2724ae0b93872538c2d369f,

title = "Measurement of cross sections for the 232Th(P,4n) 229Pa reaction at low proton energies",

abstract = "The alpha-emitters 225Ac and 213Bi are of great interest for alpha-radioimmunotherapy which uses radioisotopes attached to cancer-seeking antibodies to efficiently treat various types of cancers. Both radioisotopes are daughters of the long-lived 229Th(t 1/2=7880y). 229Th can be produced by proton irradiation of 232Th and 230Th, either directly or through production of isobars that beta-decay into 229Th. To obtain excitation functions, 232Th and 230Th have been irradiated at the On-Line Test Facility at the Holifield Radioactive Ion Beam Facility at ORNL. Benchmark tests conducted with Cu and Ni foils show very good agreement with literature results. The experiments with thorium targets were focused on the production of 229Pa and its daughter 225Ac from both 232Th and 230Th. Differential cross-sections for production of 229Pa and other Pa isotopes have been obtained.",

keywords = "Accelerator, Medical isotopes, Thorium",

author = "Jost, {C. U.} and Griswold, {J. R.} and Bruffey, {S. H.} and S. Mirzadeh and Stracener, {D. W.} and Williams, {C. L.}",

year = "2013",

doi = "10.1063/1.4802383",

language = "English",

isbn = "9780735411487",

series = "AIP Conference Proceedings",

pages = "520--524",

booktitle = "Application of Accelerators in Research and Industry - Twenty-Second International Conference",

note = "22nd International Conference on the Application of Accelerators in Research and Industry, CAARI 2012 ; Conference date: 05-08-2012 Through 10-08-2012",

}

Jost, CU, Griswold, JR, Bruffey, SH, Mirzadeh, S, Stracener, DW & Williams, CL 2013, Measurement of cross sections for the ²³²Th(P,4n) ²²⁹Pa reaction at low proton energies. in Application of Accelerators in Research and Industry - Twenty-Second International Conference. AIP Conference Proceedings, vol. 1525, pp. 520-524, 22nd International Conference on the Application of Accelerators in Research and Industry, CAARI 2012, Fort Worth, TX, United States, 08/5/12. https://doi.org/10.1063/1.4802383

Measurement of cross sections for the ²³²Th(P,4n) ²²⁹Pa reaction at low proton energies. / Jost, C. U.; Griswold, J. R.; Bruffey, S. H. et al.
Application of Accelerators in Research and Industry - Twenty-Second International Conference. 2013. p. 520-524 (AIP Conference Proceedings; Vol. 1525).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Jost, C. U.

AU - Griswold, J. R.

AU - Bruffey, S. H.

AU - Mirzadeh, S.

AU - Stracener, D. W.

AU - Williams, C. L.

PY - 2013

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N2 - The alpha-emitters 225Ac and 213Bi are of great interest for alpha-radioimmunotherapy which uses radioisotopes attached to cancer-seeking antibodies to efficiently treat various types of cancers. Both radioisotopes are daughters of the long-lived 229Th(t 1/2=7880y). 229Th can be produced by proton irradiation of 232Th and 230Th, either directly or through production of isobars that beta-decay into 229Th. To obtain excitation functions, 232Th and 230Th have been irradiated at the On-Line Test Facility at the Holifield Radioactive Ion Beam Facility at ORNL. Benchmark tests conducted with Cu and Ni foils show very good agreement with literature results. The experiments with thorium targets were focused on the production of 229Pa and its daughter 225Ac from both 232Th and 230Th. Differential cross-sections for production of 229Pa and other Pa isotopes have been obtained.

AB - The alpha-emitters 225Ac and 213Bi are of great interest for alpha-radioimmunotherapy which uses radioisotopes attached to cancer-seeking antibodies to efficiently treat various types of cancers. Both radioisotopes are daughters of the long-lived 229Th(t 1/2=7880y). 229Th can be produced by proton irradiation of 232Th and 230Th, either directly or through production of isobars that beta-decay into 229Th. To obtain excitation functions, 232Th and 230Th have been irradiated at the On-Line Test Facility at the Holifield Radioactive Ion Beam Facility at ORNL. Benchmark tests conducted with Cu and Ni foils show very good agreement with literature results. The experiments with thorium targets were focused on the production of 229Pa and its daughter 225Ac from both 232Th and 230Th. Differential cross-sections for production of 229Pa and other Pa isotopes have been obtained.

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