Making a hybrid microfluidic platform compatible for in situ imaging by vacuum-based techniques

Li Yang; Xiao Ying Yu; Zihua Zhu; Theva Thevuthasan; James P. Cowin

doi:10.1116/1.3654147

Making a hybrid microfluidic platform compatible for in situ imaging by vacuum-based techniques

Li Yang, Xiao Ying Yu, Zihua Zhu, Theva Thevuthasan, James P. Cowin

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

A self-contained microfluidic-based device was designed and fabricated for in situ imaging of aqueous surfaces using vacuum techniques. The device is a hybrid between a microfluidic poly(dimethyl siloxane) block and external accessories, all portable on a small platform (10 × 8 cm ²). The key feature is that a small aperture with a diameter of 2-3 μm is opened to the vacuum, which serves as a detection window for in situ imaging of aqueous surfaces. Vacuum compatibility and temperature drop due to water vaporization are the two most important challenges in this invention. Theoretical calculations and fabrication strategies are presented from multiple design aspects. In addition, results from the time-of-flight secondary ion mass spectrometry and scanning electron microscopy of aqueous surfaces are presented.

Original language	English
Article number	061101
Journal	Journal of Vacuum Science and Technology, Part A: Vacuum, Surfaces and Films
Volume	29
Issue number	6
DOIs	https://doi.org/10.1116/1.3654147
State	Published - Nov 2011
Externally published	Yes

Funding

We are grateful for the support from the Department of Energy (DOE) Division of Chemical Sciences, Geosciences, and Biosciences (BES Chemical Sciences Grant No. KC-0301020-16248) and the Office of Biological and Environmental Research (OBER). The research was performed in the W. R. Wiley Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility sponsored by OBER and located at the Pacific Northwest National Laboratory (PNNL). PNNL is operated for the DOE by Battelle.

Funders	Funder number
OBER
U.S. Department of Energy
Basic Energy Sciences	KC-0301020-16248
Biological and Environmental Research
Chemical Sciences, Geosciences, and Biosciences Division

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Making a hybrid microfluidic platform compatible for in situ imaging by vacuum-based techniques

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