TY - JOUR
T1 - Lipid membranes loaded with Ca2+ and Zn2+ cations
AU - Kučerka, N.
AU - Dushanov, E.
AU - Kholmurodov, K. T.
AU - Katsaras, J.
AU - Uhríková, D.
N1 - Publisher Copyright:
© Published under licence by IOP Publishing Ltd.
PY - 2017/6/8
Y1 - 2017/6/8
N2 - We have studied the interactions of calcium and zinc with the biomimetic membrane made of dipalmitoyl-phosphatidylcholine (DPPC). The small angle neutron experiment on oriented multilamellar samples showed clearly differences in the effects of the two cations. For both, a bilayer thickness increases due to divalent metal ion (Me2+) binding, reaching the maximum at stoichiometry Me2+:DPPC∼1:7 mol/mol. However, while the further increase in Ca2+ results in a bilayer thinning down to the level of pure DPPC, the Zn2+ binding indicates the behaviour of a typical isotherm, reaching a level of saturation.
AB - We have studied the interactions of calcium and zinc with the biomimetic membrane made of dipalmitoyl-phosphatidylcholine (DPPC). The small angle neutron experiment on oriented multilamellar samples showed clearly differences in the effects of the two cations. For both, a bilayer thickness increases due to divalent metal ion (Me2+) binding, reaching the maximum at stoichiometry Me2+:DPPC∼1:7 mol/mol. However, while the further increase in Ca2+ results in a bilayer thinning down to the level of pure DPPC, the Zn2+ binding indicates the behaviour of a typical isotherm, reaching a level of saturation.
UR - http://www.scopus.com/inward/record.url?scp=85022029070&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/848/1/012008
DO - 10.1088/1742-6596/848/1/012008
M3 - Conference article
AN - SCOPUS:85022029070
SN - 1742-6588
VL - 848
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
IS - 1
M1 - 012008
T2 - 3rd International Conference on Small Angle Neutron Scattering Dedicated to the 80th Anniversary of Yu.M. Ostanevich, YuMO 2016
Y2 - 6 June 2016 through 9 June 2016
ER -