TY - JOUR
T1 - Isotopic analysis of Nd nanoparticles using single particle MC-ICP-MS
T2 - A comparative study with single particle-ICP-TOF-MS
AU - Manard, Benjamin T.
AU - Bradley, Veronica C.
AU - Hendriks, Lyndsey
AU - Dunlap, Daniel R.
AU - Zirakparvar, N. Alex
AU - Ticknor, Brian W.
AU - Toro-Gonzalez, Miguel
AU - Andrews, Hunter B.
N1 - Publisher Copyright:
© 2025 Elsevier B.V.
PY - 2025/5/1
Y1 - 2025/5/1
N2 - Single particle - inductively coupled plasma - mass spectrometry (SP-ICP-MS) is a powerful technique for characterization of the elemental and isotopic composition of individual particles. In this work, the capabilities of the newest generation of MC-ICP-MS with acquisition rates down to 50 ms were evaluated for single particle analysis, with a focus on isotopic precision achievable on a single-particle level. Nd (NdVO4) nanoparticles (∼120 nm in diameter) were used as case study and were first characterized in terms of mass (respective size) and particle number concentration by SP-ICP-TOF-MS and then by SP-MC-ICP-MS for isotopic precision. For the isotopic ratio measurements, the MC-ICP-MS performance was compared to the ICP-TOF-MS and it was found that the isotope ratio precision was increased (R2 between 0.98 and 0.99) compared to ICP-TOF-MS (R2 between 0.88 and 0.97). The accuracy attained on a single particle level, was compared to bulk digestion followed by MC-ICP-MS analysis, and the SP-MC-ICP-MS technique was able to determine the particle population average to be <4 %, percent relative differences for the 142Nd/144Nd, 143Nd/144Nd, 145Nd/144Nd, 146Nd/144Nd, and 148Nd/144Nd ratios The detection limit for the SP-MC-ICP-MS approach was also assessed. When utilizing an all Faraday-cup based detection scheme the determined LOD for the measurements was 0.2 fg for Nd, per particle. Based on these results, the newest generation of MC-ICP-MS has demonstrated its utility for performing SP measurement, particularly when high precision isotopic determination is warranted.
AB - Single particle - inductively coupled plasma - mass spectrometry (SP-ICP-MS) is a powerful technique for characterization of the elemental and isotopic composition of individual particles. In this work, the capabilities of the newest generation of MC-ICP-MS with acquisition rates down to 50 ms were evaluated for single particle analysis, with a focus on isotopic precision achievable on a single-particle level. Nd (NdVO4) nanoparticles (∼120 nm in diameter) were used as case study and were first characterized in terms of mass (respective size) and particle number concentration by SP-ICP-TOF-MS and then by SP-MC-ICP-MS for isotopic precision. For the isotopic ratio measurements, the MC-ICP-MS performance was compared to the ICP-TOF-MS and it was found that the isotope ratio precision was increased (R2 between 0.98 and 0.99) compared to ICP-TOF-MS (R2 between 0.88 and 0.97). The accuracy attained on a single particle level, was compared to bulk digestion followed by MC-ICP-MS analysis, and the SP-MC-ICP-MS technique was able to determine the particle population average to be <4 %, percent relative differences for the 142Nd/144Nd, 143Nd/144Nd, 145Nd/144Nd, 146Nd/144Nd, and 148Nd/144Nd ratios The detection limit for the SP-MC-ICP-MS approach was also assessed. When utilizing an all Faraday-cup based detection scheme the determined LOD for the measurements was 0.2 fg for Nd, per particle. Based on these results, the newest generation of MC-ICP-MS has demonstrated its utility for performing SP measurement, particularly when high precision isotopic determination is warranted.
KW - ICP-MS
KW - ICP-TOF-MS
KW - Isotopic ratio
KW - MC-ICP-MS
KW - Nanoparticle
KW - Single particle
UR - http://www.scopus.com/inward/record.url?scp=85214347946&partnerID=8YFLogxK
U2 - 10.1016/j.talanta.2025.127516
DO - 10.1016/j.talanta.2025.127516
M3 - Article
AN - SCOPUS:85214347946
SN - 0039-9140
VL - 286
JO - Talanta
JF - Talanta
M1 - 127516
ER -