Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

Kejin Zhou; Petra Kos; Yunfeng Yan; Hu Xiong; Yi Li Min; Karina A. Kinghorn; Jonathan T. Minnig; Jason B. Miller; Daniel J. Siegwart

doi:10.1039/c6cc06024b

Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

Kejin Zhou, Petra Kos, Yunfeng Yan, Hu Xiong, Yi Li Min, Karina A. Kinghorn, Jonathan T. Minnig, Jason B. Miller, Daniel J. Siegwart

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.

Original language	English
Pages (from-to)	12155-12158
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	82
DOIs	https://doi.org/10.1039/c6cc06024b
State	Published - 2016
Externally published	Yes

Access to Document

10.1039/c6cc06024b

Cite this

@article{ab10964e66ae4e409f8aaeea81570f80,

title = "Intercalation-mediated nucleic acid nanoparticles for siRNA delivery",

abstract = "Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.",

author = "Kejin Zhou and Petra Kos and Yunfeng Yan and Hu Xiong and Min, \{Yi Li\} and Kinghorn, \{Karina A.\} and Minnig, \{Jonathan T.\} and Miller, \{Jason B.\} and Siegwart, \{Daniel J.\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

doi = "10.1039/c6cc06024b",

language = "English",

volume = "52",

pages = "12155--12158",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "82",

}

TY - JOUR

T1 - Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

AU - Zhou, Kejin

AU - Kos, Petra

AU - Yan, Yunfeng

AU - Xiong, Hu

AU - Min, Yi Li

AU - Kinghorn, Karina A.

AU - Minnig, Jonathan T.

AU - Miller, Jason B.

AU - Siegwart, Daniel J.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2016.

PY - 2016

Y1 - 2016

N2 - Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.

AB - Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.

UR - https://www.scopus.com/pages/publications/84991211626

U2 - 10.1039/c6cc06024b

DO - 10.1039/c6cc06024b

M3 - Article

C2 - 27711272

AN - SCOPUS:84991211626

SN - 1359-7345

VL - 52

SP - 12155

EP - 12158

JO - Chemical Communications

JF - Chemical Communications

IS - 82

ER -

Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

Abstract

Access to Document

Other files and links

Fingerprint

Cite this