Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

Kejin Zhou; Petra Kos; Yunfeng Yan; Hu Xiong; Yi Li Min; Karina A. Kinghorn; Jonathan T. Minnig; Jason B. Miller; Daniel J. Siegwart

doi:10.1039/c6cc06024b

Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

Kejin Zhou, Petra Kos, Yunfeng Yan, Hu Xiong, Yi Li Min, Karina A. Kinghorn, Jonathan T. Minnig, Jason B. Miller, Daniel J. Siegwart

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.

Original language	English
Pages (from-to)	12155-12158
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	82
DOIs	https://doi.org/10.1039/c6cc06024b
State	Published - 2016
Externally published	Yes

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10.1039/c6cc06024b

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title = "Intercalation-mediated nucleic acid nanoparticles for siRNA delivery",

abstract = "Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.",

author = "Kejin Zhou and Petra Kos and Yunfeng Yan and Hu Xiong and Min, {Yi Li} and Kinghorn, {Karina A.} and Minnig, {Jonathan T.} and Miller, {Jason B.} and Siegwart, {Daniel J.}",

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pages = "12155--12158",

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TY - JOUR

T1 - Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

AU - Zhou, Kejin

AU - Kos, Petra

AU - Yan, Yunfeng

AU - Xiong, Hu

AU - Min, Yi Li

AU - Kinghorn, Karina A.

AU - Minnig, Jonathan T.

AU - Miller, Jason B.

AU - Siegwart, Daniel J.

PY - 2016

Y1 - 2016

N2 - Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.

AB - Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.

UR - http://www.scopus.com/inward/record.url?scp=84991211626&partnerID=8YFLogxK

U2 - 10.1039/c6cc06024b

DO - 10.1039/c6cc06024b

M3 - Article

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AN - SCOPUS:84991211626

SN - 1359-7345

VL - 52

SP - 12155

EP - 12158

JO - Chemical Communications

JF - Chemical Communications

IS - 82

ER -

Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

Abstract

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