In vitro performance of a perfusion and oxygenation optical sensor using a unique liver phantom

Tony J. Akl, Travis J. King, Ruiqi Long, M. Nance Ericson, Mark A. Wilson, Michael J. McShane, Gerard L. Coté

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations

Abstract

Between the years 1999 and 2008, on average 2,052 people died per year on the waiting list for liver transplants. Monitoring perfusion and oxygenation in transplanted organs in the 7 to 14 days period post-transplant can enhance graft and patient survival rates, and resultantly increase the availability of organs. In this work, we present in vitro results using a unique liver phantom that support the ability of our sensor to detect perfusion changes in the portal vein at low levels (50 mL/min ≈ 4.5% of normal level). Our sensor measures diffuse reflection from three wavelengths (735, 805 and 940 nm) around the hemoglobin isobestic point (805 nm) to determine perfusion and oxygenation separately. To assess the sensitivity of our sensor to flow changes in the low range, we used two peristaltic pumps to pump a dye solution mimicking the optical properties of oxygenated blood, at various rates, through a PDMS based phantom mimicking the optical properties of liver tissue. The collected pulsatile signal increased by 120% (2.2X) for every 100 mL/min flow rise for all three wavelengths in the range 50 to 500 mL/min. In addition, we used different dye mixtures to mimic oxygenation changes at constant perfusion/flow levels. The optical properties of the dye mixtures mimic oxygen saturations ranging between 0 and 100%. The sensor was shown to be sensitive to changes in oxygen saturations above 50%.

Original languageEnglish
Title of host publicationOptical Diagnostics and Sensing XII
Subtitle of host publicationToward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV
DOIs
StatePublished - 2012
EventOptical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV - San Francisco, CA, United States
Duration: Jan 21 2012Jan 26 2012

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8229
ISSN (Print)1605-7422

Conference

ConferenceOptical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV
Country/TerritoryUnited States
CitySan Francisco, CA
Period01/21/1201/26/12

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