In vitro Cytotoxicity of Half-Sandwich Platinum Group Metal Complexes of a Cationic Alkylated Phosphaadamantane Ligand

Andrew R. Burgoyne; Catherine H. Kaschula; M. Iqbal Parker; Gregory S. Smith

doi:10.1002/ejic.201501458

In vitro Cytotoxicity of Half-Sandwich Platinum Group Metal Complexes of a Cationic Alkylated Phosphaadamantane Ligand

Andrew R. Burgoyne, Catherine H. Kaschula, M. Iqbal Parker, Gregory S. Smith

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Trinuclear and model mononuclear cationic monodentate Rh^III, Ir^III and Ru^II complexes with alkylated 1,3,5-triaza-7-phosphaadamantane (PTA) moieties have been prepared and characterized using NMR and IR spectroscopy, HR-ESI mass spectrometry and elemental analysis. The metals coordinate to the ligands via the phosphorus of the PTA, and this was confirmed by shifts in the ³¹P{¹H} NMR spectra. The cytotoxicities of all the compounds were investigated against the WHCO1 esophageal cancer cell line. The Ir^III mononuclear complex proved to be the most cytotoxic. Additionally, ¹H NMR model studies demonstrated its DNA binding ability while UV/Vis studies demonstrated the ability of the iridium mononuclear complex to interact with the double helix structure of Red Salmon testes DNA.

Original language	English
Pages (from-to)	1267-1273
Number of pages	7
Journal	European Journal of Inorganic Chemistry
Volume	2016
Issue number	8
DOIs	https://doi.org/10.1002/ejic.201501458
State	Published - Mar 1 2016
Externally published	Yes

Funding

Financial support from the University of Cape Town and the National Research Foundation (NRF) of South Africa is gratefully acknowledged.

Funders	Funder number
National Research Foundation
University of Cape Town

Keywords

Antitumor agents
Bioorganometallic chemistry
DNA binding
Half-sandwich complexes
Medicinal chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ejic.201501458

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title = "In vitro Cytotoxicity of Half-Sandwich Platinum Group Metal Complexes of a Cationic Alkylated Phosphaadamantane Ligand",

abstract = "Trinuclear and model mononuclear cationic monodentate RhIII, IrIII and RuII complexes with alkylated 1,3,5-triaza-7-phosphaadamantane (PTA) moieties have been prepared and characterized using NMR and IR spectroscopy, HR-ESI mass spectrometry and elemental analysis. The metals coordinate to the ligands via the phosphorus of the PTA, and this was confirmed by shifts in the 31P{1H} NMR spectra. The cytotoxicities of all the compounds were investigated against the WHCO1 esophageal cancer cell line. The IrIII mononuclear complex proved to be the most cytotoxic. Additionally, 1H NMR model studies demonstrated its DNA binding ability while UV/Vis studies demonstrated the ability of the iridium mononuclear complex to interact with the double helix structure of Red Salmon testes DNA.",

keywords = "Antitumor agents, Bioorganometallic chemistry, DNA binding, Half-sandwich complexes, Medicinal chemistry",

author = "Burgoyne, {Andrew R.} and Kaschula, {Catherine H.} and Parker, {M. Iqbal} and Smith, {Gregory S.}",

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doi = "10.1002/ejic.201501458",

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T1 - In vitro Cytotoxicity of Half-Sandwich Platinum Group Metal Complexes of a Cationic Alkylated Phosphaadamantane Ligand

AU - Burgoyne, Andrew R.

AU - Kaschula, Catherine H.

AU - Parker, M. Iqbal

AU - Smith, Gregory S.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Trinuclear and model mononuclear cationic monodentate RhIII, IrIII and RuII complexes with alkylated 1,3,5-triaza-7-phosphaadamantane (PTA) moieties have been prepared and characterized using NMR and IR spectroscopy, HR-ESI mass spectrometry and elemental analysis. The metals coordinate to the ligands via the phosphorus of the PTA, and this was confirmed by shifts in the 31P{1H} NMR spectra. The cytotoxicities of all the compounds were investigated against the WHCO1 esophageal cancer cell line. The IrIII mononuclear complex proved to be the most cytotoxic. Additionally, 1H NMR model studies demonstrated its DNA binding ability while UV/Vis studies demonstrated the ability of the iridium mononuclear complex to interact with the double helix structure of Red Salmon testes DNA.

AB - Trinuclear and model mononuclear cationic monodentate RhIII, IrIII and RuII complexes with alkylated 1,3,5-triaza-7-phosphaadamantane (PTA) moieties have been prepared and characterized using NMR and IR spectroscopy, HR-ESI mass spectrometry and elemental analysis. The metals coordinate to the ligands via the phosphorus of the PTA, and this was confirmed by shifts in the 31P{1H} NMR spectra. The cytotoxicities of all the compounds were investigated against the WHCO1 esophageal cancer cell line. The IrIII mononuclear complex proved to be the most cytotoxic. Additionally, 1H NMR model studies demonstrated its DNA binding ability while UV/Vis studies demonstrated the ability of the iridium mononuclear complex to interact with the double helix structure of Red Salmon testes DNA.

KW - Antitumor agents

KW - Bioorganometallic chemistry

KW - DNA binding

KW - Half-sandwich complexes

KW - Medicinal chemistry

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JO - European Journal of Inorganic Chemistry

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ER -

In vitro Cytotoxicity of Half-Sandwich Platinum Group Metal Complexes of a Cationic Alkylated Phosphaadamantane Ligand

Abstract

Funding

Keywords

UN SDGs

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