In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates

Hyuk Sang Yoo; Tae Gwan Park

In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates

Hyuk Sang Yoo, Tae Gwan Park

Research output: Contribution to journal › Conference article › peer-review

17 Scopus citations

Abstract

Doxorubicin was conjugated to poly(D,L-lactic-co-glycolic acid) (PLGA) by an ester linkage that can be cleavable under physiological conditions. The nanoparticles containing doxorubicin-PLGA conjugates were characterized in terms of size, zeta potential, and drug loading. In vitro sustained release profiles of doxorubicin from nanoparticles were examined by conjugating two different molecular weights of PLGA. In vitro anti-cancer activity of doxorubicin nanoparticles into HepG2 cells was quantified by a flow cytometry method and visualized using a confocal microscopy. In vivo anti-tumor activity was also studied.

Original language	English
Pages (from-to)	992-993
Number of pages	2
Journal	American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume	41
Issue number	1
State	Published - Mar 2000
Externally published	Yes
Event	The San Francisco Meeting - San Francisco, CA, USA Duration: Mar 26 2000 → Mar 31 2000

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title = "In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates",

abstract = "Doxorubicin was conjugated to poly(D,L-lactic-co-glycolic acid) (PLGA) by an ester linkage that can be cleavable under physiological conditions. The nanoparticles containing doxorubicin-PLGA conjugates were characterized in terms of size, zeta potential, and drug loading. In vitro sustained release profiles of doxorubicin from nanoparticles were examined by conjugating two different molecular weights of PLGA. In vitro anti-cancer activity of doxorubicin nanoparticles into HepG2 cells was quantified by a flow cytometry method and visualized using a confocal microscopy. In vivo anti-tumor activity was also studied.",

author = "Yoo, {Hyuk Sang} and Park, {Tae Gwan}",

year = "2000",

month = mar,

language = "English",

volume = "41",

pages = "992--993",

journal = "American Chemical Society, Polymer Preprints, Division of Polymer Chemistry",

issn = "0032-3934",

number = "1",

note = "The San Francisco Meeting ; Conference date: 26-03-2000 Through 31-03-2000",

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T1 - In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates

AU - Yoo, Hyuk Sang

AU - Park, Tae Gwan

PY - 2000/3

Y1 - 2000/3

N2 - Doxorubicin was conjugated to poly(D,L-lactic-co-glycolic acid) (PLGA) by an ester linkage that can be cleavable under physiological conditions. The nanoparticles containing doxorubicin-PLGA conjugates were characterized in terms of size, zeta potential, and drug loading. In vitro sustained release profiles of doxorubicin from nanoparticles were examined by conjugating two different molecular weights of PLGA. In vitro anti-cancer activity of doxorubicin nanoparticles into HepG2 cells was quantified by a flow cytometry method and visualized using a confocal microscopy. In vivo anti-tumor activity was also studied.

AB - Doxorubicin was conjugated to poly(D,L-lactic-co-glycolic acid) (PLGA) by an ester linkage that can be cleavable under physiological conditions. The nanoparticles containing doxorubicin-PLGA conjugates were characterized in terms of size, zeta potential, and drug loading. In vitro sustained release profiles of doxorubicin from nanoparticles were examined by conjugating two different molecular weights of PLGA. In vitro anti-cancer activity of doxorubicin nanoparticles into HepG2 cells was quantified by a flow cytometry method and visualized using a confocal microscopy. In vivo anti-tumor activity was also studied.

UR - http://www.scopus.com/inward/record.url?scp=0033734338&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0033734338

SN - 0032-3934

VL - 41

SP - 992

EP - 993

JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry

IS - 1

T2 - The San Francisco Meeting

Y2 - 26 March 2000 through 31 March 2000

ER -

In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates

Abstract

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