In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel

Shuo Wang; Oju Jeon; Peter G. Shankles; Yuan Liu; Eben Alsberg; Scott T. Retterer; Bruce P. Lee; Chang Kyoung Choi

doi:10.1063/1.4941339

In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel

Shuo Wang, Oju Jeon, Peter G. Shankles, Yuan Liu, Eben Alsberg, Scott T. Retterer, Bruce P. Lee, Chang Kyoung Choi

Center for Nanophase Matls Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We present a simple microfluidic technique to in-situ photopolymerize (by 365 nm ultraviolet) monodisperse oxidized methacrylated alginate (OMA) microgels using a photoinitiator (VA-086). By this technique, we generated monodisperse sphericalOMA beads and discoid non-spherical beads with better shape consistency than ionic crosslinking methods do. We found that a high monomer concentration (8 w/v%), a high photoinitiator concentration (1.5w/v %), and absence of oxygen are critical factors to cure OMA microgels. This photopolymerizing method is an alternative to current methods to form alginate microgels and is a simpler approach to generatenon-spherical alginate microgels.

Original language	English
Article number	011101
Journal	Biomicrofluidics
Volume	10
Issue number	1
DOIs	https://doi.org/10.1063/1.4941339
State	Published - Jan 1 2016

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© 2016 AIP Publishing LLC.

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abstract = "We present a simple microfluidic technique to in-situ photopolymerize (by 365 nm ultraviolet) monodisperse oxidized methacrylated alginate (OMA) microgels using a photoinitiator (VA-086). By this technique, we generated monodisperse sphericalOMA beads and discoid non-spherical beads with better shape consistency than ionic crosslinking methods do. We found that a high monomer concentration (8 w/v%), a high photoinitiator concentration (1.5w/v %), and absence of oxygen are critical factors to cure OMA microgels. This photopolymerizing method is an alternative to current methods to form alginate microgels and is a simpler approach to generatenon-spherical alginate microgels.",

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AU - Wang, Shuo

AU - Jeon, Oju

AU - Shankles, Peter G.

AU - Liu, Yuan

AU - Alsberg, Eben

AU - Retterer, Scott T.

AU - Lee, Bruce P.

AU - Choi, Chang Kyoung

PY - 2016/1/1

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N2 - We present a simple microfluidic technique to in-situ photopolymerize (by 365 nm ultraviolet) monodisperse oxidized methacrylated alginate (OMA) microgels using a photoinitiator (VA-086). By this technique, we generated monodisperse sphericalOMA beads and discoid non-spherical beads with better shape consistency than ionic crosslinking methods do. We found that a high monomer concentration (8 w/v%), a high photoinitiator concentration (1.5w/v %), and absence of oxygen are critical factors to cure OMA microgels. This photopolymerizing method is an alternative to current methods to form alginate microgels and is a simpler approach to generatenon-spherical alginate microgels.

AB - We present a simple microfluidic technique to in-situ photopolymerize (by 365 nm ultraviolet) monodisperse oxidized methacrylated alginate (OMA) microgels using a photoinitiator (VA-086). By this technique, we generated monodisperse sphericalOMA beads and discoid non-spherical beads with better shape consistency than ionic crosslinking methods do. We found that a high monomer concentration (8 w/v%), a high photoinitiator concentration (1.5w/v %), and absence of oxygen are critical factors to cure OMA microgels. This photopolymerizing method is an alternative to current methods to form alginate microgels and is a simpler approach to generatenon-spherical alginate microgels.

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In-situ photopolymerization of monodisperse and discoid oxidized methacrylated alginate microgels in a microfluidic channel

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