TY - CHAP
T1 - In silico recognition of protein-protein interactions
T2 - Theory and applications
AU - Park, Byung Hoon
AU - Dam, Phuongan
AU - Pan, Chongle
AU - Xu, Ying
AU - Geist, Al
AU - Heffelfinger, Grant
AU - Samatova, Nagiza F.
PY - 2006
Y1 - 2006
N2 - Protein-protein interactions are fundamental to cellular processes. They are responsible for phenomena like DNA replication, gene transcription, protein translation, regulation of metabolic pathways, immunologic recognition, signal transduction, etc. The identification of interacting proteins is therefore an important prerequisite step in understanding their physiological functions. Due to the invaluable importance to various biophysical activities, reliable computational methods to infer protein-protein interactions from either structural or genome sequences are in heavy demand lately. Successful predictions, for instance, will facilitate a drug design process and the reconstruction of metabolic or regulatory networks. In this chapter, we review: (a) high-throughput experimental methods for identification of protein-protein interactions, (b) existing databases of protein-protein interactions, (c) computational approaches to predicting protein-protein interactions at both residue and protein levels, (d) various statistical and machine learning techniques to model protein-protein interactions, and (e) applications of protein-protein interactions in predicting protein functions. We also discuss intrinsic drawbacks of the existing approaches and future research directions.
AB - Protein-protein interactions are fundamental to cellular processes. They are responsible for phenomena like DNA replication, gene transcription, protein translation, regulation of metabolic pathways, immunologic recognition, signal transduction, etc. The identification of interacting proteins is therefore an important prerequisite step in understanding their physiological functions. Due to the invaluable importance to various biophysical activities, reliable computational methods to infer protein-protein interactions from either structural or genome sequences are in heavy demand lately. Successful predictions, for instance, will facilitate a drug design process and the reconstruction of metabolic or regulatory networks. In this chapter, we review: (a) high-throughput experimental methods for identification of protein-protein interactions, (b) existing databases of protein-protein interactions, (c) computational approaches to predicting protein-protein interactions at both residue and protein levels, (d) various statistical and machine learning techniques to model protein-protein interactions, and (e) applications of protein-protein interactions in predicting protein functions. We also discuss intrinsic drawbacks of the existing approaches and future research directions.
UR - http://www.scopus.com/inward/record.url?scp=84900139738&partnerID=8YFLogxK
U2 - 10.4018/978-1-59140-863-5.ch013
DO - 10.4018/978-1-59140-863-5.ch013
M3 - Chapter
AN - SCOPUS:84900139738
SN - 9781591408635
SP - 248
EP - 268
BT - Advanced Data Mining Technologies in Bioinformatics
PB - IGI Global
ER -