TY - GEN
T1 - IN-LINE DEGASSER AND INTEGRATED 3D PRINTED PLATFORM TO INCREASE THE POWER OF ENGINEERED ON-CHIP CULTURE MODELS
AU - Saleheen, Amirus
AU - Musgrove, Hannah B.
AU - Pompano, Rebecca R.
N1 - Publisher Copyright:
© 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Recent years have witnessed significant growth of engineered 3D culture systems under microfluidic flow control (e.g., organs-on-chip), but viability studies in these systems are often hindered by nutrient flow interruption by gas bubbles in the media lines. Additionally, scaling up requires handling dozens of chips inside a culture incubator requiring mechanistic arrangements for proper handling. To solve these problems, a mass-producible in-line degassing module and an integrated, 3D-printed platform for robust organization of arrays of chips were developed. The system was tested with a recently described micropatterned 3D culture of human immune cells.
AB - Recent years have witnessed significant growth of engineered 3D culture systems under microfluidic flow control (e.g., organs-on-chip), but viability studies in these systems are often hindered by nutrient flow interruption by gas bubbles in the media lines. Additionally, scaling up requires handling dozens of chips inside a culture incubator requiring mechanistic arrangements for proper handling. To solve these problems, a mass-producible in-line degassing module and an integrated, 3D-printed platform for robust organization of arrays of chips were developed. The system was tested with a recently described micropatterned 3D culture of human immune cells.
KW - 3D Culture-On-Chip
KW - High Throughput Microfluidics
KW - In-Line Degasser
KW - Stereolithography 3D Printing
UR - http://www.scopus.com/inward/record.url?scp=85136988793&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85136988793
T3 - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 1437
EP - 1438
BT - MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Y2 - 10 October 2021 through 14 October 2021
ER -
