Immobilization of Adenosine Derivatives onto Cellulose Nanocrystals via Click Chemistry for Biocatalysis Applications

Célestin Bourgery; David Joram Mendoza; Gil Garnier; Louis M.M. Mouterde; Florent Allais

doi:10.1021/acsami.3c19025

Immobilization of Adenosine Derivatives onto Cellulose Nanocrystals via Click Chemistry for Biocatalysis Applications

Célestin Bourgery, David Joram Mendoza, Gil Garnier, Louis M.M. Mouterde, Florent Allais

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Adenosine triphosphate (ATP) is a central molecule of organisms and is involved in many biological processes. It is also widely used in biocatalytic processes, especially as a substrate and precursor of many cofactors─such as nicotinamide adenine dinucleotide phosphate (NADP(H)), coenzyme A (CoA), and S-adenosylmethionine (SAM). Despite its great scientific interest and pivotal role, its use in industrial processes is impeded by its prohibitory cost. To overcome this limitation, we developed a greener synthesis of adenosine derivatives and efficiently selectively grafted them onto organic nanoparticles. In this study, cellulose nanocrystals were used as a model combined with click chemistry via a copper-catalyzed azide/alkyne cycloaddition reaction (CuAAC). The grafted adenosine triphosphate derivative fully retains its biocatalytic capability, enabling heterobiocatalysis for modern biochemical processes.

Original language	English
Pages (from-to)	11315-11323
Number of pages	9
Journal	ACS Applied Materials and Interfaces
Volume	16
Issue number	9
DOIs	https://doi.org/10.1021/acsami.3c19025
State	Published - Mar 6 2024
Externally published	Yes

Funding

This work was supported by the Région Grand Est, Conseil Départemental de la Marne and Grand Reims. C. Bourgery would like to thank BioPRIA of the Department of Chemical and Biological Engineering, Monash University for hosting him for 2 months. Many thanks to Y. Hora of Monash X-ray Platform (MXP) for the XPS analysis.

Keywords

ATP immobilization
CNCs
biocatalysis
click-chemistry
cofactor
nanocellulose

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10.1021/acsami.3c19025

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title = "Immobilization of Adenosine Derivatives onto Cellulose Nanocrystals via Click Chemistry for Biocatalysis Applications",

abstract = "Adenosine triphosphate (ATP) is a central molecule of organisms and is involved in many biological processes. It is also widely used in biocatalytic processes, especially as a substrate and precursor of many cofactors─such as nicotinamide adenine dinucleotide phosphate (NADP(H)), coenzyme A (CoA), and S-adenosylmethionine (SAM). Despite its great scientific interest and pivotal role, its use in industrial processes is impeded by its prohibitory cost. To overcome this limitation, we developed a greener synthesis of adenosine derivatives and efficiently selectively grafted them onto organic nanoparticles. In this study, cellulose nanocrystals were used as a model combined with click chemistry via a copper-catalyzed azide/alkyne cycloaddition reaction (CuAAC). The grafted adenosine triphosphate derivative fully retains its biocatalytic capability, enabling heterobiocatalysis for modern biochemical processes.",

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T1 - Immobilization of Adenosine Derivatives onto Cellulose Nanocrystals via Click Chemistry for Biocatalysis Applications

AU - Bourgery, Célestin

AU - Mendoza, David Joram

AU - Garnier, Gil

AU - Mouterde, Louis M.M.

AU - Allais, Florent

PY - 2024/3/6

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AB - Adenosine triphosphate (ATP) is a central molecule of organisms and is involved in many biological processes. It is also widely used in biocatalytic processes, especially as a substrate and precursor of many cofactors─such as nicotinamide adenine dinucleotide phosphate (NADP(H)), coenzyme A (CoA), and S-adenosylmethionine (SAM). Despite its great scientific interest and pivotal role, its use in industrial processes is impeded by its prohibitory cost. To overcome this limitation, we developed a greener synthesis of adenosine derivatives and efficiently selectively grafted them onto organic nanoparticles. In this study, cellulose nanocrystals were used as a model combined with click chemistry via a copper-catalyzed azide/alkyne cycloaddition reaction (CuAAC). The grafted adenosine triphosphate derivative fully retains its biocatalytic capability, enabling heterobiocatalysis for modern biochemical processes.

KW - ATP immobilization

KW - CNCs

KW - biocatalysis

KW - click-chemistry

KW - cofactor

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IS - 9

ER -

Immobilization of Adenosine Derivatives onto Cellulose Nanocrystals via Click Chemistry for Biocatalysis Applications

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