Identifying Fungal Secondary Metabolites and Their Role in Plant Pathogenesis

Joanna Tannous; Jesse Labbé; Nancy P. Keller

doi:10.1007/978-1-0716-3159-1_15

Identifying Fungal Secondary Metabolites and Their Role in Plant Pathogenesis

Joanna Tannous
, Jesse Labbé
, Nancy P. Keller

Synthetic Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

5 Scopus citations

Abstract

Pathogenic fungi are the main infectious agents of plants. Secondary metabolites produced by these fungi, also recognized as natural products, are key mediators of plant-fungal interactions. Knowledge on the biosynthesis of these metabolites, the accessibility to fungal genome sequences, and the development of gene disruption techniques open up opportunities to identify many more of these metabolites both in vitro and in planta. This methodology chapter gives a detailed systematic approach aiming to discover new natural products from phytopathogenic fungi and characterize their role in triggering plant cell death and plant disease. This approach takes advantage of the global regulation of fungal secondary metabolite production by regulatory proteins reported in various fungal species.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	193-218
Number of pages	26
DOIs	https://doi.org/10.1007/978-1-0716-3159-1_15
State	Published - 2023

Publication series

Name	Methods in Molecular Biology
Volume	2659
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

Funding

The Secure Ecosystem Engineering and Design (SEED) (https:// seed-sfa.ornl.gov/) project is funded by the Genomic Science Program of the US Department of Energy, Office of Science, Office of Biological and Environmental Research (BER), as part of the Secure Biosystems Design Science Focus Area (SFA). All figures were created with http://www.biorender.com/.

Keywords

Bioinformatics
Biosynthetic gene clusters
Fungal secondary metabolites
Fungal-plant interactions
Phytopathogenic fungi
Plant pathogenesis

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10.1007/978-1-0716-3159-1_15

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title = "Identifying Fungal Secondary Metabolites and Their Role in Plant Pathogenesis",

abstract = "Pathogenic fungi are the main infectious agents of plants. Secondary metabolites produced by these fungi, also recognized as natural products, are key mediators of plant-fungal interactions. Knowledge on the biosynthesis of these metabolites, the accessibility to fungal genome sequences, and the development of gene disruption techniques open up opportunities to identify many more of these metabolites both in vitro and in planta. This methodology chapter gives a detailed systematic approach aiming to discover new natural products from phytopathogenic fungi and characterize their role in triggering plant cell death and plant disease. This approach takes advantage of the global regulation of fungal secondary metabolite production by regulatory proteins reported in various fungal species.",

keywords = "Bioinformatics, Biosynthetic gene clusters, Fungal secondary metabolites, Fungal-plant interactions, Phytopathogenic fungi, Plant pathogenesis",

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note = "Publisher Copyright: {\textcopyright} 2023, His Majesty the King in Right of Canada, as represented by the Minister of Agriculture and Agri-Food.",

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language = "English",

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T1 - Identifying Fungal Secondary Metabolites and Their Role in Plant Pathogenesis

AU - Tannous, Joanna

AU - Labbé, Jesse

AU - Keller, Nancy P.

PY - 2023

Y1 - 2023

N2 - Pathogenic fungi are the main infectious agents of plants. Secondary metabolites produced by these fungi, also recognized as natural products, are key mediators of plant-fungal interactions. Knowledge on the biosynthesis of these metabolites, the accessibility to fungal genome sequences, and the development of gene disruption techniques open up opportunities to identify many more of these metabolites both in vitro and in planta. This methodology chapter gives a detailed systematic approach aiming to discover new natural products from phytopathogenic fungi and characterize their role in triggering plant cell death and plant disease. This approach takes advantage of the global regulation of fungal secondary metabolite production by regulatory proteins reported in various fungal species.

AB - Pathogenic fungi are the main infectious agents of plants. Secondary metabolites produced by these fungi, also recognized as natural products, are key mediators of plant-fungal interactions. Knowledge on the biosynthesis of these metabolites, the accessibility to fungal genome sequences, and the development of gene disruption techniques open up opportunities to identify many more of these metabolites both in vitro and in planta. This methodology chapter gives a detailed systematic approach aiming to discover new natural products from phytopathogenic fungi and characterize their role in triggering plant cell death and plant disease. This approach takes advantage of the global regulation of fungal secondary metabolite production by regulatory proteins reported in various fungal species.

KW - Bioinformatics

KW - Biosynthetic gene clusters

KW - Fungal secondary metabolites

KW - Fungal-plant interactions

KW - Phytopathogenic fungi

KW - Plant pathogenesis

UR - https://www.scopus.com/pages/publications/85160874264

U2 - 10.1007/978-1-0716-3159-1_15

DO - 10.1007/978-1-0716-3159-1_15

M3 - Chapter

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AN - SCOPUS:85160874264

T3 - Methods in Molecular Biology

SP - 193

EP - 218

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -

Identifying Fungal Secondary Metabolites and Their Role in Plant Pathogenesis

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Keywords

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