Identification of druggable genome in staphylococcus aureus multidrug resistant strain

Maria Batool; Sangdun Choi

doi:10.1109/LSC.2017.8268195

Identification of druggable genome in staphylococcus aureus multidrug resistant strain

Maria Batool, Sangdun Choi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Scopus citations

Abstract

The persistent use of antibiotics for many years has transformed numerous organisms into multiple drug resistant. This has made the domain of drug discovery vital to cure several infectious diseases. Staphylococcus aureus is a Gram-positive bacterium that has developed resistance to multiple drugs. The main objective of this study is to identify the potential drug targets. The subtractive genomics approach was applied to screen out vital proteins. For the identification and characterization of non-homologous essential proteins, different bioinformatics tools and databases were utilized. These essential drug targets are crucial for pathogen survival and therefore can be potential targets for computer-Aided drug discovery.

Original language	English
Title of host publication	2017 IEEE Life Sciences Conference, LSC 2017
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	270-273
Number of pages	4
ISBN (Electronic)	9781538610305
DOIs	https://doi.org/10.1109/LSC.2017.8268195
State	Published - Jul 2 2017
Externally published	Yes
Event	1st International IEEE Life-Science Conference, LSC 2017 - Sydney, Australia Duration: Dec 13 2017 → Dec 15 2017

Publication series

Name	2017 IEEE Life Sciences Conference, LSC 2017
Volume	2018-January

Conference

Conference	1st International IEEE Life-Science Conference, LSC 2017
Country/Territory	Australia
City	Sydney
Period	12/13/17 → 12/15/17

Funding

ACKNOWLEDGMENT This work was supported by the National Research Foundation of Korea (NRF-2015R1A2A2A09001059, NRF 2012–0006687).

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10.1109/LSC.2017.8268195

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title = "Identification of druggable genome in staphylococcus aureus multidrug resistant strain",

abstract = "The persistent use of antibiotics for many years has transformed numerous organisms into multiple drug resistant. This has made the domain of drug discovery vital to cure several infectious diseases. Staphylococcus aureus is a Gram-positive bacterium that has developed resistance to multiple drugs. The main objective of this study is to identify the potential drug targets. The subtractive genomics approach was applied to screen out vital proteins. For the identification and characterization of non-homologous essential proteins, different bioinformatics tools and databases were utilized. These essential drug targets are crucial for pathogen survival and therefore can be potential targets for computer-Aided drug discovery.",

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doi = "10.1109/LSC.2017.8268195",

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Batool, M & Choi, S 2017, Identification of druggable genome in staphylococcus aureus multidrug resistant strain. in 2017 IEEE Life Sciences Conference, LSC 2017. 2017 IEEE Life Sciences Conference, LSC 2017, vol. 2018-January, Institute of Electrical and Electronics Engineers Inc., pp. 270-273, 1st International IEEE Life-Science Conference, LSC 2017, Sydney, Australia, 12/13/17. https://doi.org/10.1109/LSC.2017.8268195

Identification of druggable genome in staphylococcus aureus multidrug resistant strain. / Batool, Maria; Choi, Sangdun.
2017 IEEE Life Sciences Conference, LSC 2017. Institute of Electrical and Electronics Engineers Inc., 2017. p. 270-273 (2017 IEEE Life Sciences Conference, LSC 2017; Vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - The persistent use of antibiotics for many years has transformed numerous organisms into multiple drug resistant. This has made the domain of drug discovery vital to cure several infectious diseases. Staphylococcus aureus is a Gram-positive bacterium that has developed resistance to multiple drugs. The main objective of this study is to identify the potential drug targets. The subtractive genomics approach was applied to screen out vital proteins. For the identification and characterization of non-homologous essential proteins, different bioinformatics tools and databases were utilized. These essential drug targets are crucial for pathogen survival and therefore can be potential targets for computer-Aided drug discovery.

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Identification of druggable genome in staphylococcus aureus multidrug resistant strain

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