TY - JOUR
T1 - Identification of antioxidant phenolic compounds in feverfew (Tanacetum parthenium) by HPLC-ESI-MS/MS and NMR
AU - Wu, Changqing
AU - Chen, Feng
AU - Wang, Xi
AU - Wu, Yonnie
AU - Dong, Meidul
AU - He, Guoqing
AU - Galyean, Ronald D.
AU - He, Lilin
AU - Huang, Guohui
PY - 2007/9
Y1 - 2007/9
N2 - Antioxidant polyphenolic acids in the medicinal herb feverfew (Tanacetum parthenium) were isolated through in vitro bioassay-orientated antioxidant tests in response to 1,1-diphenyl-2-picrylhydrazyl (DPPH•,) free radical scavenging and Fe2+-chelating activities. Purification of the active compounds and their structural elucidation involved a variety of techniques including open-column chromatography, HPLC, GC-MS, LC-MS and NMR. Major compounds with potent DPPH•, scavenging activities were characterlsed as 3,5-, 4,5- and 3,4-di-O-caffeoylquinic acids (DCQAs). This is the first report of DCQAs found in feverfew.
AB - Antioxidant polyphenolic acids in the medicinal herb feverfew (Tanacetum parthenium) were isolated through in vitro bioassay-orientated antioxidant tests in response to 1,1-diphenyl-2-picrylhydrazyl (DPPH•,) free radical scavenging and Fe2+-chelating activities. Purification of the active compounds and their structural elucidation involved a variety of techniques including open-column chromatography, HPLC, GC-MS, LC-MS and NMR. Major compounds with potent DPPH•, scavenging activities were characterlsed as 3,5-, 4,5- and 3,4-di-O-caffeoylquinic acids (DCQAs). This is the first report of DCQAs found in feverfew.
KW - Antioxidant
KW - Dicaffeoylquinic acid
KW - Feverfew
KW - LC-MS
KW - NMR
KW - Phenolics
UR - http://www.scopus.com/inward/record.url?scp=34548721609&partnerID=8YFLogxK
U2 - 10.1002/pca.995
DO - 10.1002/pca.995
M3 - Article
C2 - 17624900
AN - SCOPUS:34548721609
SN - 0958-0344
VL - 18
SP - 401
EP - 410
JO - Phytochemical Analysis
JF - Phytochemical Analysis
IS - 5
ER -