Hybrid Valve Structure for High-Throughput, Low-Volume Liquid-Handling Applications

Mitchel J. Doktycz; James E. Johnson; Mary J. Cornett

doi:10.1016/j.jala.2004.04.019

Hybrid Valve Structure for High-Throughput, Low-Volume Liquid-Handling Applications

Mitchel J. Doktycz, James E. Johnson, Mary J. Cornett

Biosciences Division

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A hybrid valve that integrates precision microfluidics for fluid routing, high-speed valving for fluid switching, and reagent-jetting devices for metering the fluid dispenses is described. The hybrid valve enables parallel switching between aspiration and dispense modes for multiple sample streams. This unique valve structure addresses many of the concerns with handling microscale volumes, including efficient use of samples, degradation of ink jet valves and speed of operation. A broad range of volumes can be manipulated with excellent reproducibility. The hybrid valve can be configured for a variety of applications. Pick-and-place aspiration and dispensing of unique reagents and rapid dispensing of a common reagent are possible. Together these features lead to higher-speed transfer of smaller volumes of reagent.

Original language	English
Pages (from-to)	250-256
Number of pages	7
Journal	Journal of Laboratory Automation
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/j.jala.2004.04.019
State	Published - Aug 2004

Funding

This research was sponsored by the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory (ORNL), managed by UT-Battelle, LLC for the U.S. Department of Energy under Contract No. DE-AC05-00OR22725 00OR22725 in collaboration with Innovadyne Technologies, a privately held, instrument device manufacturer, Santa Rosa, CA. Special thanks to Dave Hunter, Dave Martin, Neil Picha, Craig Storms (Innovadyne Technologies, Inc.), and Steve Hicks (ORNL) for their contributions and support. This manuscript has been authored by a contractor of the U.S.Government under Contract No. DE-AC05-00OR22725. Accordingly, the U.S. Government retains a nonexclusive, royalty-free license to publish or reproduce the published form of this contribution, or allow others to do so, for U.S. Government purposes.

Funders	Funder number
U.S.Government	DE-AC05-00OR22725
U.S. Department of Energy	DE-AC05-00OR22725 00OR22725
Oak Ridge National Laboratory
UT-Battelle

Keywords

automated liquid
handling
high-throughput
ink-jet
microdispensing
reagent-jet
screening

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10.1016/j.jala.2004.04.019

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title = "Hybrid Valve Structure for High-Throughput, Low-Volume Liquid-Handling Applications",

abstract = "A hybrid valve that integrates precision microfluidics for fluid routing, high-speed valving for fluid switching, and reagent-jetting devices for metering the fluid dispenses is described. The hybrid valve enables parallel switching between aspiration and dispense modes for multiple sample streams. This unique valve structure addresses many of the concerns with handling microscale volumes, including efficient use of samples, degradation of ink jet valves and speed of operation. A broad range of volumes can be manipulated with excellent reproducibility. The hybrid valve can be configured for a variety of applications. Pick-and-place aspiration and dispensing of unique reagents and rapid dispensing of a common reagent are possible. Together these features lead to higher-speed transfer of smaller volumes of reagent.",

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author = "Doktycz, {Mitchel J.} and Johnson, {James E.} and Cornett, {Mary J.}",

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AU - Cornett, Mary J.

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AB - A hybrid valve that integrates precision microfluidics for fluid routing, high-speed valving for fluid switching, and reagent-jetting devices for metering the fluid dispenses is described. The hybrid valve enables parallel switching between aspiration and dispense modes for multiple sample streams. This unique valve structure addresses many of the concerns with handling microscale volumes, including efficient use of samples, degradation of ink jet valves and speed of operation. A broad range of volumes can be manipulated with excellent reproducibility. The hybrid valve can be configured for a variety of applications. Pick-and-place aspiration and dispensing of unique reagents and rapid dispensing of a common reagent are possible. Together these features lead to higher-speed transfer of smaller volumes of reagent.

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KW - handling

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KW - reagent-jet

KW - screening

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ER -

Hybrid Valve Structure for High-Throughput, Low-Volume Liquid-Handling Applications

Abstract

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Keywords

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