Heterotrimeric G-protein signaling in Arabidopsis: Puzzling G-protein-coupled receptor

Jin Gui Chen

doi:10.4161/psb.3.12.6064

Heterotrimeric G-protein signaling in Arabidopsis: Puzzling G-protein-coupled receptor

Jin Gui Chen

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Seven transmembrane G-protein-coupled receptors (GPCRs) are commonly used by eukaryotes to sense extracellular signals to switch on cellular responses through the activation of cognate heterotrimeric G-proteins. In Arabidopsis thaliana, GCR2 has been proposed as a GPCR for the plant hormone abscisic acid. On the other hand, biochemical analysis demonstrates that the sole Arabidopsis heterotrimeric G-protein α subunit, GPA1, is in the activated state (GTP-bound) by default, suggesting that the heterotrimeric G-proteins may act without any GPCRs.

Original language	English
Pages (from-to)	1042-1045
Number of pages	4
Journal	Plant Signaling and Behavior
Volume	3
Issue number	12
DOIs	https://doi.org/10.4161/psb.3.12.6064
State	Published - Dec 2008
Externally published	Yes

Funding

I thank Dr. Francis Willard and Dr. Alan Jones (University of North Carolina at Chapel Hill) for invaluable comments. Work in my laboratory on heterotrimeric G-proteins is supported by grants from NSERC and CFI.

Funders	Funder number
Natural Sciences and Engineering Research Council of Canada
Canada Foundation for Innovation

Keywords

AtRGS1
G-protein-coupled receptor (GPCR)
GCR2
GPA1
Heterotrimeric G-proteins

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10.4161/psb.3.12.6064

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title = "Heterotrimeric G-protein signaling in Arabidopsis: Puzzling G-protein-coupled receptor",

abstract = "Seven transmembrane G-protein-coupled receptors (GPCRs) are commonly used by eukaryotes to sense extracellular signals to switch on cellular responses through the activation of cognate heterotrimeric G-proteins. In Arabidopsis thaliana, GCR2 has been proposed as a GPCR for the plant hormone abscisic acid. On the other hand, biochemical analysis demonstrates that the sole Arabidopsis heterotrimeric G-protein α subunit, GPA1, is in the activated state (GTP-bound) by default, suggesting that the heterotrimeric G-proteins may act without any GPCRs.",

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AB - Seven transmembrane G-protein-coupled receptors (GPCRs) are commonly used by eukaryotes to sense extracellular signals to switch on cellular responses through the activation of cognate heterotrimeric G-proteins. In Arabidopsis thaliana, GCR2 has been proposed as a GPCR for the plant hormone abscisic acid. On the other hand, biochemical analysis demonstrates that the sole Arabidopsis heterotrimeric G-protein α subunit, GPA1, is in the activated state (GTP-bound) by default, suggesting that the heterotrimeric G-proteins may act without any GPCRs.

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KW - G-protein-coupled receptor (GPCR)

KW - GCR2

KW - GPA1

KW - Heterotrimeric G-proteins

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JO - Plant Signaling and Behavior

JF - Plant Signaling and Behavior

IS - 12

ER -

Heterotrimeric G-protein signaling in Arabidopsis: Puzzling G-protein-coupled receptor

Abstract

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Keywords

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