Abstract
Synaptic plasticity refers to activity-dependent synaptic strengthening or weakening between neurons. It is usually associated with homosynaptic plasticity, which refers to a synaptic junction controlled by interactions between specific neurons. Heterosynaptic plasticity, on the other hand, lacks this specificity. It involves much larger populations of synapses and neurons and can be associated with changes in synaptic strength due to nonlocal alterations in the ambient electrochemical environment. This paper presents specific examples demonstrating how variations in the ambient electrochemical environment of lipid membranes can impact the nonlinear dynamical behaviors of memristive and memcapacitive systems in droplet interface bilayers (DIBs). Examples include the use of pH as a modulatory factor that alters the voltage-dependent memristive behavior of alamethicin ion channels in DIB lipid bilayers, and the discovery of long-term potentiation (LTP) in a lipid bilayer-only system after application of electrical stimulation protocols. Graphical abstract: (Figure presented.)
| Original language | English |
|---|---|
| Pages (from-to) | 565-573 |
| Number of pages | 9 |
| Journal | MRS Advances |
| Volume | 9 |
| Issue number | 9 |
| DOIs | |
| State | Published - Jul 2024 |
Funding
J.K. and C.P.C. are supported through the Scientific User Facilities Division of the Department of Energy (DOE) Office of Science, sponsored by the Basic Energy Science (BES) Program, DOE Office of Science, under Contract No. DE-AC05-00OR22725. D.B. is supported through the National Science Foundation, Division of Molecular and Cellular Biosciences (MCB), under contract No. 2219289. Manuscript preparation was performed at the Center for Nanophase Materials Sciences, a US DOE Office of Science User Facility. This manuscript has been authored by UT-Battelle, LLC, under contract DE-AC05-00OR22725 with the US Department of Energy (DOE). The US government retains and the publisher, by accepting the article for publication, acknowledges that the US government retains a nonexclusive, paid-up, irrevocable, worldwide license to publish or reproduce the published form of this manuscript, or allow others to do so, for US government purposes. DOE will provide public access to these results of federally sponsored research in accordance with the DOE Public Access Plan ( http://energy.gov/downloads/doe-public-access-plan ).
| Funders | Funder number |
|---|---|
| National Science Foundation | |
| U.S. Department of Energy | |
| Division of Molecular and Cellular Biosciences | 2219289 |
| Office of Science | |
| Basic Energy Sciences | DE-AC05-00OR22725 |