Gold Nanoparticles with Antibiotic-Metallopolymers toward Broad-Spectrum Antibacterial Effects

Peng Yang; Parasmani Pageni; Md Anisur Rahman; Marpe Bam; Tianyu Zhu; Yung Pin Chen; Mitzi Nagarkatti; Alan W. Decho; Chuanbing Tang

doi:10.1002/adhm.201800854

Gold Nanoparticles with Antibiotic-Metallopolymers toward Broad-Spectrum Antibacterial Effects

Peng Yang, Parasmani Pageni, Md Anisur Rahman, Marpe Bam, Tianyu Zhu, Yung Pin Chen, Mitzi Nagarkatti, Alan W. Decho, Chuanbing Tang

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Bacterial infection has evolved into one of the most dangerous global health crises. Designing potent antimicrobial agents that can combat drug-resistant bacteria is essential for treating bacterial infections. In this paper, a strategy to graft metallopolymer-antibiotic bioconjugates on gold nanoparticles is developed as an antibacterial agent to fight against different bacterial strains. Thus, these nanoparticle conjugates combine various components in one system to display enhanced bactericidal efficacy, in which small sized nanoparticles provide high surface area for bacteria to contact, cationic metallopolymers interact with the negatively charged bacterial membranes, and the β-lactam antibiotics' sterilzation capabilities are improved via evading intracellular enzymolysis by β-lactamase. This nanoparticle-based antibiotic-metallopolymer system exhibits an excellent broad-spectrum antibacterial effect, particularly for Gram-negative bacteria, due to the synergistic effect of multicomponents on the interaction with bacteria.

Original language	English
Article number	1800854
Journal	Advanced Healthcare Materials
Volume	8
Issue number	6
DOIs	https://doi.org/10.1002/adhm.201800854
State	Published - Mar 21 2019
Externally published	Yes

Funding

P.Y. and P.P. contributed equally to this work. The support from National Institutes of Health (R01AI120987) is acknowledged.

Funders	Funder number
National Institutes of Health
National Institute of Allergy and Infectious Diseases	R01AI120987

Keywords

antibiotics
antimicrobial
cobaltocenium
gold nanoparticles
metallopolymers

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10.1002/adhm.201800854

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title = "Gold Nanoparticles with Antibiotic-Metallopolymers toward Broad-Spectrum Antibacterial Effects",

abstract = "Bacterial infection has evolved into one of the most dangerous global health crises. Designing potent antimicrobial agents that can combat drug-resistant bacteria is essential for treating bacterial infections. In this paper, a strategy to graft metallopolymer-antibiotic bioconjugates on gold nanoparticles is developed as an antibacterial agent to fight against different bacterial strains. Thus, these nanoparticle conjugates combine various components in one system to display enhanced bactericidal efficacy, in which small sized nanoparticles provide high surface area for bacteria to contact, cationic metallopolymers interact with the negatively charged bacterial membranes, and the β-lactam antibiotics' sterilzation capabilities are improved via evading intracellular enzymolysis by β-lactamase. This nanoparticle-based antibiotic-metallopolymer system exhibits an excellent broad-spectrum antibacterial effect, particularly for Gram-negative bacteria, due to the synergistic effect of multicomponents on the interaction with bacteria.",

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AU - Pageni, Parasmani

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AU - Bam, Marpe

AU - Zhu, Tianyu

AU - Chen, Yung Pin

AU - Nagarkatti, Mitzi

AU - Decho, Alan W.

AU - Tang, Chuanbing

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AB - Bacterial infection has evolved into one of the most dangerous global health crises. Designing potent antimicrobial agents that can combat drug-resistant bacteria is essential for treating bacterial infections. In this paper, a strategy to graft metallopolymer-antibiotic bioconjugates on gold nanoparticles is developed as an antibacterial agent to fight against different bacterial strains. Thus, these nanoparticle conjugates combine various components in one system to display enhanced bactericidal efficacy, in which small sized nanoparticles provide high surface area for bacteria to contact, cationic metallopolymers interact with the negatively charged bacterial membranes, and the β-lactam antibiotics' sterilzation capabilities are improved via evading intracellular enzymolysis by β-lactamase. This nanoparticle-based antibiotic-metallopolymer system exhibits an excellent broad-spectrum antibacterial effect, particularly for Gram-negative bacteria, due to the synergistic effect of multicomponents on the interaction with bacteria.

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Gold Nanoparticles with Antibiotic-Metallopolymers toward Broad-Spectrum Antibacterial Effects

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Keywords

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