Genetics: Genome streamlining in a cosmopolitan oceanic bacterium

Stephen J. Giovannoni; H. James Tripp; Scott Givan; Mircea Podar; Kevin L. Vergin; Damon Baptista; Lisa Bibbs; Jonathan Eads; Toby H. Richardson; Michiel Noordewier; Michael S. Rappé; Jay M. Short; James C. Carrington; Eric J. Mathur

doi:10.1126/science.1114057

Genetics: Genome streamlining in a cosmopolitan oceanic bacterium

Stephen J. Giovannoni
, H. James Tripp
, Scott Givan
, Mircea Podar
, Kevin L. Vergin
, Damon Baptista
, Lisa Bibbs
, Jonathan Eads
, Toby H. Richardson
, Michiel Noordewier
, Michael S. Rappé
, Jay M. Short
, James C. Carrington
, Eric J. Mathur

Research output: Contribution to journal › Article › peer-review

932 Scopus citations

Abstract

The SAR11 clade consists of very small, heterotrophic marine α-proteobarteria that are found throughout the oceans, where they account for about 25% of all microbial cells. Pelagibacter ubique, the first cultured member of this clade, has the smallest genome and encodes the smallest number of predicted open reading frames known for a free-living microorganism. In contrast to parasitic bacteria and archaea with small genomes, P. ubique has complete biosynthetic pathways for all 20 amino acids and all but a few cofactors. P. ubique has no pseudogenes, introns, transposons, extrachromosomal elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell.

Original language	English
Pages (from-to)	1242-1245
Number of pages	4
Journal	Science
Volume	309
Issue number	5738
DOIs	https://doi.org/10.1126/science.1114057
State	Published - Aug 19 2005
Externally published	Yes

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title = "Genetics: Genome streamlining in a cosmopolitan oceanic bacterium",

abstract = "The SAR11 clade consists of very small, heterotrophic marine α-proteobarteria that are found throughout the oceans, where they account for about 25\% of all microbial cells. Pelagibacter ubique, the first cultured member of this clade, has the smallest genome and encodes the smallest number of predicted open reading frames known for a free-living microorganism. In contrast to parasitic bacteria and archaea with small genomes, P. ubique has complete biosynthetic pathways for all 20 amino acids and all but a few cofactors. P. ubique has no pseudogenes, introns, transposons, extrachromosomal elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell.",

author = "Giovannoni, \{Stephen J.\} and Tripp, \{H. James\} and Scott Givan and Mircea Podar and Vergin, \{Kevin L.\} and Damon Baptista and Lisa Bibbs and Jonathan Eads and Richardson, \{Toby H.\} and Michiel Noordewier and Rapp{\'e}, \{Michael S.\} and Short, \{Jay M.\} and Carrington, \{James C.\} and Mathur, \{Eric J.\}",

year = "2005",

month = aug,

day = "19",

doi = "10.1126/science.1114057",

language = "English",

volume = "309",

pages = "1242--1245",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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}

TY - JOUR

T1 - Genetics

T2 - Genome streamlining in a cosmopolitan oceanic bacterium

AU - Giovannoni, Stephen J.

AU - Tripp, H. James

AU - Givan, Scott

AU - Podar, Mircea

AU - Vergin, Kevin L.

AU - Baptista, Damon

AU - Bibbs, Lisa

AU - Eads, Jonathan

AU - Richardson, Toby H.

AU - Noordewier, Michiel

AU - Rappé, Michael S.

AU - Short, Jay M.

AU - Carrington, James C.

AU - Mathur, Eric J.

PY - 2005/8/19

Y1 - 2005/8/19

N2 - The SAR11 clade consists of very small, heterotrophic marine α-proteobarteria that are found throughout the oceans, where they account for about 25% of all microbial cells. Pelagibacter ubique, the first cultured member of this clade, has the smallest genome and encodes the smallest number of predicted open reading frames known for a free-living microorganism. In contrast to parasitic bacteria and archaea with small genomes, P. ubique has complete biosynthetic pathways for all 20 amino acids and all but a few cofactors. P. ubique has no pseudogenes, introns, transposons, extrachromosomal elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell.

AB - The SAR11 clade consists of very small, heterotrophic marine α-proteobarteria that are found throughout the oceans, where they account for about 25% of all microbial cells. Pelagibacter ubique, the first cultured member of this clade, has the smallest genome and encodes the smallest number of predicted open reading frames known for a free-living microorganism. In contrast to parasitic bacteria and archaea with small genomes, P. ubique has complete biosynthetic pathways for all 20 amino acids and all but a few cofactors. P. ubique has no pseudogenes, introns, transposons, extrachromosomal elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell.

UR - https://www.scopus.com/pages/publications/23844446418

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DO - 10.1126/science.1114057

M3 - Article

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AN - SCOPUS:23844446418

SN - 0036-8075

VL - 309

SP - 1242

EP - 1245

JO - Science

JF - Science

IS - 5738

ER -

Genetics: Genome streamlining in a cosmopolitan oceanic bacterium

Abstract

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