Genetics: Genome streamlining in a cosmopolitan oceanic bacterium

Stephen J. Giovannoni; H. James Tripp; Scott Givan; Mircea Podar; Kevin L. Vergin; Damon Baptista; Lisa Bibbs; Jonathan Eads; Toby H. Richardson; Michiel Noordewier; Michael S. Rappé; Jay M. Short; James C. Carrington; Eric J. Mathur

doi:10.1126/science.1114057

Genetics: Genome streamlining in a cosmopolitan oceanic bacterium

Stephen J. Giovannoni, H. James Tripp, Scott Givan, Mircea Podar, Kevin L. Vergin, Damon Baptista, Lisa Bibbs, Jonathan Eads, Toby H. Richardson, Michiel Noordewier, Michael S. Rappé, Jay M. Short, James C. Carrington, Eric J. Mathur

Research output: Contribution to journal › Article › peer-review

879 Scopus citations

Abstract

The SAR11 clade consists of very small, heterotrophic marine α-proteobarteria that are found throughout the oceans, where they account for about 25% of all microbial cells. Pelagibacter ubique, the first cultured member of this clade, has the smallest genome and encodes the smallest number of predicted open reading frames known for a free-living microorganism. In contrast to parasitic bacteria and archaea with small genomes, P. ubique has complete biosynthetic pathways for all 20 amino acids and all but a few cofactors. P. ubique has no pseudogenes, introns, transposons, extrachromosomal elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell.

Original language	English
Pages (from-to)	1242-1245
Number of pages	4
Journal	Science
Volume	309
Issue number	5738
DOIs	https://doi.org/10.1126/science.1114057
State	Published - Aug 19 2005
Externally published	Yes

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title = "Genetics: Genome streamlining in a cosmopolitan oceanic bacterium",

abstract = "The SAR11 clade consists of very small, heterotrophic marine α-proteobarteria that are found throughout the oceans, where they account for about 25% of all microbial cells. Pelagibacter ubique, the first cultured member of this clade, has the smallest genome and encodes the smallest number of predicted open reading frames known for a free-living microorganism. In contrast to parasitic bacteria and archaea with small genomes, P. ubique has complete biosynthetic pathways for all 20 amino acids and all but a few cofactors. P. ubique has no pseudogenes, introns, transposons, extrachromosomal elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell.",

author = "Giovannoni, {Stephen J.} and Tripp, {H. James} and Scott Givan and Mircea Podar and Vergin, {Kevin L.} and Damon Baptista and Lisa Bibbs and Jonathan Eads and Richardson, {Toby H.} and Michiel Noordewier and Rapp{\'e}, {Michael S.} and Short, {Jay M.} and Carrington, {James C.} and Mathur, {Eric J.}",

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AU - Giovannoni, Stephen J.

AU - Tripp, H. James

AU - Givan, Scott

AU - Podar, Mircea

AU - Vergin, Kevin L.

AU - Baptista, Damon

AU - Bibbs, Lisa

AU - Eads, Jonathan

AU - Richardson, Toby H.

AU - Noordewier, Michiel

AU - Rappé, Michael S.

AU - Short, Jay M.

AU - Carrington, James C.

AU - Mathur, Eric J.

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AB - The SAR11 clade consists of very small, heterotrophic marine α-proteobarteria that are found throughout the oceans, where they account for about 25% of all microbial cells. Pelagibacter ubique, the first cultured member of this clade, has the smallest genome and encodes the smallest number of predicted open reading frames known for a free-living microorganism. In contrast to parasitic bacteria and archaea with small genomes, P. ubique has complete biosynthetic pathways for all 20 amino acids and all but a few cofactors. P. ubique has no pseudogenes, introns, transposons, extrachromosomal elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell.

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Genetics: Genome streamlining in a cosmopolitan oceanic bacterium

Abstract

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