Genetically-engineered whole-cell bioreporters on integrated circuits for environmental monitoring

N. D. Bull, S. K. Islam, B. J. Blalock, S. Ripp, S. Moser, G. S. Sayler

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

A bioluminescent bioreporter integrated circuit (BBIC) biosensor for environmental monitoring is presented. The bioluminescent bioreporters are bacteria that can be genetically altered to achieve bioluminescence when in contact with a targeted substance. The bioreporters are placed on a microluminometer. The microluminometer includes integrated photodiodes and signal processing circuits and is realized in a standard CMOS process. The BBIC can detect luminescence from as few as 5000 fully induced Pseudomonas fluorescene 5RL bacteria and provides a integrated biosensor platform for environmental and food/water safety monitoring.

Original languageEnglish
Title of host publication2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008
Pages1998-2001
Number of pages4
DOIs
StatePublished - 2008
Externally publishedYes
Event2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008 - Seattle, WA, United States
Duration: May 18 2008May 21 2008

Publication series

NameProceedings - IEEE International Symposium on Circuits and Systems
ISSN (Print)0271-4310

Conference

Conference2008 IEEE International Symposium on Circuits and Systems, ISCAS 2008
Country/TerritoryUnited States
CitySeattle, WA
Period05/18/0805/21/08

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