Gene silencing by siRNA microhydrogels via polymeric nanoscale condensation

Cheol Am Hong; Soo Hyeon Lee; Jee Seon Kim; Ji Won Park; Ki Hyun Bae; Hyejung Mok; Tae Gwan Park; Haeshin Lee

doi:10.1021/ja2056984

Gene silencing by siRNA microhydrogels via polymeric nanoscale condensation

Cheol Am Hong
, Soo Hyeon Lee
, Jee Seon Kim
, Ji Won Park
, Ki Hyun Bae
, Hyejung Mok
, Tae Gwan Park
, Haeshin Lee

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanoparticles that exhibited superb cellular uptake efficiency and gene silencing activity.

Original language	English
Pages (from-to)	13914-13917
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	35
DOIs	https://doi.org/10.1021/ja2056984
State	Published - Sep 7 2011
Externally published	Yes

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10.1021/ja2056984

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title = "Gene silencing by siRNA microhydrogels via polymeric nanoscale condensation",

abstract = "The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanoparticles that exhibited superb cellular uptake efficiency and gene silencing activity.",

author = "Hong, \{Cheol Am\} and Lee, \{Soo Hyeon\} and Kim, \{Jee Seon\} and Park, \{Ji Won\} and Bae, \{Ki Hyun\} and Hyejung Mok and Park, \{Tae Gwan\} and Haeshin Lee",

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AU - Hong, Cheol Am

AU - Lee, Soo Hyeon

AU - Kim, Jee Seon

AU - Park, Ji Won

AU - Bae, Ki Hyun

AU - Mok, Hyejung

AU - Park, Tae Gwan

AU - Lee, Haeshin

PY - 2011/9/7

Y1 - 2011/9/7

N2 - The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanoparticles that exhibited superb cellular uptake efficiency and gene silencing activity.

AB - The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanoparticles that exhibited superb cellular uptake efficiency and gene silencing activity.

UR - https://www.scopus.com/pages/publications/80052308366

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M3 - Article

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AN - SCOPUS:80052308366

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 35

ER -

Gene silencing by siRNA microhydrogels via polymeric nanoscale condensation

Abstract

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