Gene silencing by siRNA microhydrogels via polymeric nanoscale condensation

Cheol Am Hong, Soo Hyeon Lee, Jee Seon Kim, Ji Won Park, Ki Hyun Bae, Hyejung Mok, Tae Gwan Park, Haeshin Lee

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanoparticles that exhibited superb cellular uptake efficiency and gene silencing activity.

Original languageEnglish
Pages (from-to)13914-13917
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number35
DOIs
StatePublished - Sep 7 2011
Externally publishedYes

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