Functionally graded hydroxyapatite coatings doped with antibacterial components

Xiao Bai; Karren More; Christopher M. Rouleau; Afsaneh Rabiei

doi:10.1016/j.actbio.2009.12.002

Functionally graded hydroxyapatite coatings doped with antibacterial components

Xiao Bai, Karren More, Christopher M. Rouleau, Afsaneh Rabiei

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

A series of functionally graded hydroxyapatite (FGHA) coatings incorporated with various percentages of silver were deposited on titanium substrates using ion beam-assisted deposition. The analysis of the coating's cross-section using transmission electron microscopy (TEM) and scanning transmission electron microscopy equipped with energy dispersive X-ray spectroscopy has shown a decreased crystallinity as well as a distribution of nanoscale (10-50 nm) silver particles from the coating/substrate interface to top surface. Both X-ray diffraction and fast Fourier transforms on high-resolution TEM images revealed the presence of hydroxyapatite within the coatings. The amount of Ag (wt.%) on the outer surface of the FGHA, as determined from X-ray photoelectron spectroscopy, ranged from 1.09 to 6.59, which was about half of the average Ag wt.% incorporated in the entire coating. Average adhesion strengths evaluated by pull-off tests were in the range of 83 ± 6 to 88 ± 3 MPa, which is comparable to 85 MPa for FGHA without silver. Further optical observations of failed areas illustrated that the dominant failure mechanism was epoxy failure, and FGHA coating delamination was not observed.

Original language	English
Pages (from-to)	2264-2273
Number of pages	10
Journal	Acta Biomaterialia
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/j.actbio.2009.12.002
State	Published - Jun 2010

Funding

The authors would like to acknowledge the financial support from the National Science Foundation (Grant No. 0600596 ) and access to the research facilities at the Center for Nanophase Materials Sciences (CNMS) and the Shared Research Equipment (SHaRE) User Facilities at Oak Ridge National Laboratory, both of which are supported by the Scientific User Facilities Division, Office of Basic Energy Sciences, the U.S. Department of Energy (Award No. CNMS2005-070). The authors would also like to acknowledge Mr. Stefan Sandukas from NCSU for his assistance with SEM–EDS, and Drs. Harry M. Meyer, Sang Hoon Shim, Adam J. Rondinone and Andrew Payzant from ORNL for their training and assistance with XPS, nanoindentation and X-ray diffraction analysis.

Funders	Funder number
Office of Basic Energy Sciences
Scientific User Facilities Division
National Science Foundation	0600596
U.S. Department of Energy
Oak Ridge National Laboratory

Keywords

Adhesion strength
Antimicrobial
Hydroxyapatite coating
Ion beam processing

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10.1016/j.actbio.2009.12.002

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title = "Functionally graded hydroxyapatite coatings doped with antibacterial components",

abstract = "A series of functionally graded hydroxyapatite (FGHA) coatings incorporated with various percentages of silver were deposited on titanium substrates using ion beam-assisted deposition. The analysis of the coating's cross-section using transmission electron microscopy (TEM) and scanning transmission electron microscopy equipped with energy dispersive X-ray spectroscopy has shown a decreased crystallinity as well as a distribution of nanoscale (10-50 nm) silver particles from the coating/substrate interface to top surface. Both X-ray diffraction and fast Fourier transforms on high-resolution TEM images revealed the presence of hydroxyapatite within the coatings. The amount of Ag (wt.%) on the outer surface of the FGHA, as determined from X-ray photoelectron spectroscopy, ranged from 1.09 to 6.59, which was about half of the average Ag wt.% incorporated in the entire coating. Average adhesion strengths evaluated by pull-off tests were in the range of 83 ± 6 to 88 ± 3 MPa, which is comparable to 85 MPa for FGHA without silver. Further optical observations of failed areas illustrated that the dominant failure mechanism was epoxy failure, and FGHA coating delamination was not observed.",

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author = "Xiao Bai and Karren More and Rouleau, {Christopher M.} and Afsaneh Rabiei",

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AU - Bai, Xiao

AU - More, Karren

AU - Rouleau, Christopher M.

AU - Rabiei, Afsaneh

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N2 - A series of functionally graded hydroxyapatite (FGHA) coatings incorporated with various percentages of silver were deposited on titanium substrates using ion beam-assisted deposition. The analysis of the coating's cross-section using transmission electron microscopy (TEM) and scanning transmission electron microscopy equipped with energy dispersive X-ray spectroscopy has shown a decreased crystallinity as well as a distribution of nanoscale (10-50 nm) silver particles from the coating/substrate interface to top surface. Both X-ray diffraction and fast Fourier transforms on high-resolution TEM images revealed the presence of hydroxyapatite within the coatings. The amount of Ag (wt.%) on the outer surface of the FGHA, as determined from X-ray photoelectron spectroscopy, ranged from 1.09 to 6.59, which was about half of the average Ag wt.% incorporated in the entire coating. Average adhesion strengths evaluated by pull-off tests were in the range of 83 ± 6 to 88 ± 3 MPa, which is comparable to 85 MPa for FGHA without silver. Further optical observations of failed areas illustrated that the dominant failure mechanism was epoxy failure, and FGHA coating delamination was not observed.

AB - A series of functionally graded hydroxyapatite (FGHA) coatings incorporated with various percentages of silver were deposited on titanium substrates using ion beam-assisted deposition. The analysis of the coating's cross-section using transmission electron microscopy (TEM) and scanning transmission electron microscopy equipped with energy dispersive X-ray spectroscopy has shown a decreased crystallinity as well as a distribution of nanoscale (10-50 nm) silver particles from the coating/substrate interface to top surface. Both X-ray diffraction and fast Fourier transforms on high-resolution TEM images revealed the presence of hydroxyapatite within the coatings. The amount of Ag (wt.%) on the outer surface of the FGHA, as determined from X-ray photoelectron spectroscopy, ranged from 1.09 to 6.59, which was about half of the average Ag wt.% incorporated in the entire coating. Average adhesion strengths evaluated by pull-off tests were in the range of 83 ± 6 to 88 ± 3 MPa, which is comparable to 85 MPa for FGHA without silver. Further optical observations of failed areas illustrated that the dominant failure mechanism was epoxy failure, and FGHA coating delamination was not observed.

KW - Adhesion strength

KW - Antimicrobial

KW - Hydroxyapatite coating

KW - Ion beam processing

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Functionally graded hydroxyapatite coatings doped with antibacterial components

Abstract

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