FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ

Frank Stephan; Matthias Gross; Anna Grebinyk; Zakaria Aboulbanine; Zohrab Amirkhanyan; Volker Budach; Vincent Henrique Ehrhardt; Angeles Faus-Golfe; Marcus Frohme; Jean Francois Germond; James David Good; Florian Grüner; David Kaul; Mikhail Krasilnikov; Ron Leavitt; Wim Leemans; Xiangkun Li; Gregor Loisch; Frieder Müller; Georg Müller; Frank Obier; Anne Oppelt; Sebastian Philipp; Houjun Qian; Judith Reindl; Felix Riemer; Martin Sack; Michael Schmitz; Tobias Schnautz; Andreas Schüller; Theresa Staufer; Christian Stegmann; Gohar Tsakanova; Marie Catherine Vozenin; Hans Weise; Steven Worm; Daniel Zips

doi:10.1016/j.ejmp.2022.10.026

FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ

Frank Stephan, Matthias Gross, Anna Grebinyk, Zakaria Aboulbanine, Zohrab Amirkhanyan, Volker Budach, Vincent Henrique Ehrhardt, Angeles Faus-Golfe, Marcus Frohme, Jean Francois Germond, James David Good, Florian Grüner, David Kaul, Mikhail Krasilnikov, Ron Leavitt, Wim Leemans, Xiangkun Li, Gregor Loisch, Frieder Müller, Georg MüllerFrank Obier, Anne Oppelt, Sebastian Philipp, Houjun Qian, Judith Reindl, Felix Riemer, Martin Sack, Michael Schmitz, Tobias Schnautz, Andreas Schüller, Theresa Staufer, Christian Stegmann, Gohar Tsakanova, Marie Catherine Vozenin, Hans Weise, Steven Worm, Daniel Zips

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17 Scopus citations

Abstract

At the Photo Injector Test facility at DESY in Zeuthen (PITZ), an R&D platform for electron FLASH and very high energy electron radiation therapy and radiation biology is being prepared (FLASHlab@PITZ). The beam parameters available at PITZ are worldwide unique. They are based on experiences from 20 + years of developing high brightness beam sources and an ultra-intensive THz light source demonstrator for ps scale electron bunches with up to 5 nC bunch charge at MHz repetition rate in bunch trains of up to 1 ms length, currently 22 MeV (upgrade to 250 MeV planned). Individual bunches can provide peak dose rates up to 10¹⁴ Gy/s, and 10 Gy can be delivered within picoseconds. Upon demand, each bunch of the bunch train can be guided to a different transverse location, so that either a “painting” with micro beams (comparable to pencil beam scanning in proton therapy) or a cumulative increase of absorbed dose, using a wide beam distribution, can be realized at the tumor. Full tumor treatment can hence be completed within 1 ms, mitigating organ movement issues. With extremely flexible beam manipulation capabilities, FLASHlab@PITZ will cover the current parameter range of successfully demonstrated FLASH effects and extend the parameter range towards yet unexploited short treatment times and high dose rates. A summary of the plans for FLASHlab@PITZ and the status of its realization will be presented.

Original language	English
Pages (from-to)	174-187
Number of pages	14
Journal	Physica Medica
Volume	104
DOIs	https://doi.org/10.1016/j.ejmp.2022.10.026
State	Published - Dec 2022
Externally published	Yes

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Nevertheless, the work very strongly profited from the continuous support of DESY and the TH Wildau, as well as from the synergies with the high brightness electron source development for the free electron laser user facilities FLASH, the XUV and soft X-ray Free-Electron Laser Facility at DESY, and the European XFEL, as well as from the preparations for a proof-of-principle experiment for a THz SASE FEL at PITZ.

Funders	Funder number
European XFEL
Deutsches Elektronen-Synchrotron

Keywords

FLASH and VHEE radiation therapy
Flexible electron accelerator
Online image guiding
Ultra-high dose rate
Uniquely wide parameter range

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10.1016/j.ejmp.2022.10.026

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Stephan, F., Gross, M., Grebinyk, A., Aboulbanine, Z., Amirkhanyan, Z., Budach, V., Ehrhardt, V. H., Faus-Golfe, A., Frohme, M., Germond, J. F., Good, J. D., Grüner, F., Kaul, D., Krasilnikov, M., Leavitt, R., Leemans, W., Li, X., Loisch, G., Müller, F., ... Zips, D. (2022). FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ. Physica Medica, 104, 174-187. https://doi.org/10.1016/j.ejmp.2022.10.026

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title = "FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ",

abstract = "At the Photo Injector Test facility at DESY in Zeuthen (PITZ), an R&D platform for electron FLASH and very high energy electron radiation therapy and radiation biology is being prepared (FLASHlab@PITZ). The beam parameters available at PITZ are worldwide unique. They are based on experiences from 20 + years of developing high brightness beam sources and an ultra-intensive THz light source demonstrator for ps scale electron bunches with up to 5 nC bunch charge at MHz repetition rate in bunch trains of up to 1 ms length, currently 22 MeV (upgrade to 250 MeV planned). Individual bunches can provide peak dose rates up to 1014 Gy/s, and 10 Gy can be delivered within picoseconds. Upon demand, each bunch of the bunch train can be guided to a different transverse location, so that either a “painting” with micro beams (comparable to pencil beam scanning in proton therapy) or a cumulative increase of absorbed dose, using a wide beam distribution, can be realized at the tumor. Full tumor treatment can hence be completed within 1 ms, mitigating organ movement issues. With extremely flexible beam manipulation capabilities, FLASHlab@PITZ will cover the current parameter range of successfully demonstrated FLASH effects and extend the parameter range towards yet unexploited short treatment times and high dose rates. A summary of the plans for FLASHlab@PITZ and the status of its realization will be presented.",

keywords = "FLASH and VHEE radiation therapy, Flexible electron accelerator, Online image guiding, Ultra-high dose rate, Uniquely wide parameter range",

author = "Frank Stephan and Matthias Gross and Anna Grebinyk and Zakaria Aboulbanine and Zohrab Amirkhanyan and Volker Budach and Ehrhardt, {Vincent Henrique} and Angeles Faus-Golfe and Marcus Frohme and Germond, {Jean Francois} and Good, {James David} and Florian Gr{\"u}ner and David Kaul and Mikhail Krasilnikov and Ron Leavitt and Wim Leemans and Xiangkun Li and Gregor Loisch and Frieder M{\"u}ller and Georg M{\"u}ller and Frank Obier and Anne Oppelt and Sebastian Philipp and Houjun Qian and Judith Reindl and Felix Riemer and Martin Sack and Michael Schmitz and Tobias Schnautz and Andreas Sch{\"u}ller and Theresa Staufer and Christian Stegmann and Gohar Tsakanova and Vozenin, {Marie Catherine} and Hans Weise and Steven Worm and Daniel Zips",

note = "Publisher Copyright: {\textcopyright} 2022 Associazione Italiana di Fisica Medica e Sanitaria",

year = "2022",

month = dec,

doi = "10.1016/j.ejmp.2022.10.026",

language = "English",

volume = "104",

pages = "174--187",

journal = "Physica Medica",

issn = "1120-1797",

publisher = "Elsevier",

}

Stephan, F, Gross, M, Grebinyk, A, Aboulbanine, Z, Amirkhanyan, Z, Budach, V, Ehrhardt, VH, Faus-Golfe, A, Frohme, M, Germond, JF, Good, JD, Grüner, F, Kaul, D, Krasilnikov, M, Leavitt, R, Leemans, W, Li, X, Loisch, G, Müller, F, Müller, G, Obier, F, Oppelt, A, Philipp, S, Qian, H, Reindl, J, Riemer, F, Sack, M, Schmitz, M, Schnautz, T, Schüller, A, Staufer, T, Stegmann, C, Tsakanova, G, Vozenin, MC, Weise, H, Worm, S & Zips, D 2022, 'FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ', Physica Medica, vol. 104, pp. 174-187. https://doi.org/10.1016/j.ejmp.2022.10.026

TY - JOUR

T1 - FLASHlab@PITZ

T2 - New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ

AU - Stephan, Frank

AU - Gross, Matthias

AU - Grebinyk, Anna

AU - Aboulbanine, Zakaria

AU - Amirkhanyan, Zohrab

AU - Budach, Volker

AU - Ehrhardt, Vincent Henrique

AU - Faus-Golfe, Angeles

AU - Frohme, Marcus

AU - Germond, Jean Francois

AU - Good, James David

AU - Grüner, Florian

AU - Kaul, David

AU - Krasilnikov, Mikhail

AU - Leavitt, Ron

AU - Leemans, Wim

AU - Li, Xiangkun

AU - Loisch, Gregor

AU - Müller, Frieder

AU - Müller, Georg

AU - Obier, Frank

AU - Oppelt, Anne

AU - Philipp, Sebastian

AU - Qian, Houjun

AU - Reindl, Judith

AU - Riemer, Felix

AU - Sack, Martin

AU - Schmitz, Michael

AU - Schnautz, Tobias

AU - Schüller, Andreas

AU - Staufer, Theresa

AU - Stegmann, Christian

AU - Tsakanova, Gohar

AU - Vozenin, Marie Catherine

AU - Weise, Hans

AU - Worm, Steven

AU - Zips, Daniel

PY - 2022/12

Y1 - 2022/12

N2 - At the Photo Injector Test facility at DESY in Zeuthen (PITZ), an R&D platform for electron FLASH and very high energy electron radiation therapy and radiation biology is being prepared (FLASHlab@PITZ). The beam parameters available at PITZ are worldwide unique. They are based on experiences from 20 + years of developing high brightness beam sources and an ultra-intensive THz light source demonstrator for ps scale electron bunches with up to 5 nC bunch charge at MHz repetition rate in bunch trains of up to 1 ms length, currently 22 MeV (upgrade to 250 MeV planned). Individual bunches can provide peak dose rates up to 1014 Gy/s, and 10 Gy can be delivered within picoseconds. Upon demand, each bunch of the bunch train can be guided to a different transverse location, so that either a “painting” with micro beams (comparable to pencil beam scanning in proton therapy) or a cumulative increase of absorbed dose, using a wide beam distribution, can be realized at the tumor. Full tumor treatment can hence be completed within 1 ms, mitigating organ movement issues. With extremely flexible beam manipulation capabilities, FLASHlab@PITZ will cover the current parameter range of successfully demonstrated FLASH effects and extend the parameter range towards yet unexploited short treatment times and high dose rates. A summary of the plans for FLASHlab@PITZ and the status of its realization will be presented.

AB - At the Photo Injector Test facility at DESY in Zeuthen (PITZ), an R&D platform for electron FLASH and very high energy electron radiation therapy and radiation biology is being prepared (FLASHlab@PITZ). The beam parameters available at PITZ are worldwide unique. They are based on experiences from 20 + years of developing high brightness beam sources and an ultra-intensive THz light source demonstrator for ps scale electron bunches with up to 5 nC bunch charge at MHz repetition rate in bunch trains of up to 1 ms length, currently 22 MeV (upgrade to 250 MeV planned). Individual bunches can provide peak dose rates up to 1014 Gy/s, and 10 Gy can be delivered within picoseconds. Upon demand, each bunch of the bunch train can be guided to a different transverse location, so that either a “painting” with micro beams (comparable to pencil beam scanning in proton therapy) or a cumulative increase of absorbed dose, using a wide beam distribution, can be realized at the tumor. Full tumor treatment can hence be completed within 1 ms, mitigating organ movement issues. With extremely flexible beam manipulation capabilities, FLASHlab@PITZ will cover the current parameter range of successfully demonstrated FLASH effects and extend the parameter range towards yet unexploited short treatment times and high dose rates. A summary of the plans for FLASHlab@PITZ and the status of its realization will be presented.

KW - FLASH and VHEE radiation therapy

KW - Flexible electron accelerator

KW - Online image guiding

KW - Ultra-high dose rate

KW - Uniquely wide parameter range

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U2 - 10.1016/j.ejmp.2022.10.026

DO - 10.1016/j.ejmp.2022.10.026

M3 - Article

C2 - 36463582

AN - SCOPUS:85143507145

SN - 1120-1797

VL - 104

SP - 174

EP - 187

JO - Physica Medica

JF - Physica Medica

ER -

FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ

Abstract

Funding

Keywords

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