Familial Risk of Biliary Tract Cancers: A Population-Based Study in Utah

N. Jewel Samadder; Ken Robert Smith; Jathine Wong; Heidi Hanson; Kenneth Boucher; Randall W. Burt; Michael Charlton; Kathryn R. Byrne; Juan F. Gallegos-Orozco; Cathryn Koptiuch; Karen Curtin

doi:10.1007/s10620-016-4310-3

Familial Risk of Biliary Tract Cancers: A Population-Based Study in Utah

N. Jewel Samadder, Ken Robert Smith, Jathine Wong, Heidi Hanson, Kenneth Boucher, Randall W. Burt, Michael Charlton, Kathryn R. Byrne, Juan F. Gallegos-Orozco, Cathryn Koptiuch, Karen Curtin

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Background and Objectives: Biliary tract cancers (BTC) including, cholangiocarcinoma (CC) and gallbladder cancer (GBC), are rare and highly fatal malignancies. The etiology and inherited susceptibility of both malignancies are poorly understood. We quantified the risk of BTC in first-degree (FDR), second-degree (SDR), and first cousin (FC) relatives of individuals with BTC, stratified by tumor subsite. Methods: BTC diagnosed between 1980 and 2011 were identified from the Utah Cancer Registry and linked to pedigrees from the Utah Population Database. Age- and gender-matched BTC-free controls were selected to form the comparison group for determining BTC risk in relatives using Cox regression analysis. Results: Of the 1302 index patients diagnosed with BTC, 550 (42.2 %) were located in the gallbladder and 752 (57.8 %) were cholangiocarcinomas. There was no elevated risk of BTC (all subsites combined) in FDRs (HR 0.94, 95 % CI 0.29–3.0), SDRs (HR 0.25, 95 % CI 0.06–1.03), and FCs (HR 0.96, 95 % CI 0.61–1.51) of BTC cases compared to cancer-free controls. Similarly, no increased familial risk of GBC or CC was found in relatives of BTC patients stratified by tumor subsite compared to relatives of controls. Conclusions: Relatives of BTC patients are not at an increased risk of GBC or CC in a statewide population. This suggests that biliary tract cancer risk is not associated with a familial predisposition and may be mitigated more strongly by environmental modifiers.

Original language	English
Pages (from-to)	3627-3632
Number of pages	6
Journal	Digestive Diseases and Sciences
Volume	61
Issue number	12
DOIs	https://doi.org/10.1007/s10620-016-4310-3
State	Published - Dec 1 2016
Externally published	Yes

Funding

The study was funded by the National Cancer Institute, American College of Gastroenterology, American Society for Gastrointestinal Endoscopy, and the Huntsman Cancer Foundation. The funding sources did not play a role in the design, conduct or reporting of the study or in the decision to submit the manuscript for publication. Support for this project was provided by NCI Grants P01-CA073992 (RWB), R01-CA040641 (RWB), an Endoscopic Research Award from the American Society for Gastrointestinal Endoscopy (NJS), and a Junior Faculty Career Development Award from the American College of Gastroenterology (NJS). Partial support for the Utah Population Database and this project was provided by the Huntsman Cancer Institute Cancer Center Support Grant P30CA042014 from the National Cancer institute and the Huntsman Cancer Foundation. Support for the Utah Cancer Registry is provided by Contract #HHSN 261201000026C from the National Cancer Institute with additional support from the Utah Department of Health and the University of Utah.

Keywords

Biliary tract
Cholangiocarcinoma
Familial
Gallbladder cancer

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10.1007/s10620-016-4310-3

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@article{0f3cfe4cfb5e4421984f4f7650cf0d1c,

title = "Familial Risk of Biliary Tract Cancers: A Population-Based Study in Utah",

abstract = "Background and Objectives: Biliary tract cancers (BTC) including, cholangiocarcinoma (CC) and gallbladder cancer (GBC), are rare and highly fatal malignancies. The etiology and inherited susceptibility of both malignancies are poorly understood. We quantified the risk of BTC in first-degree (FDR), second-degree (SDR), and first cousin (FC) relatives of individuals with BTC, stratified by tumor subsite. Methods: BTC diagnosed between 1980 and 2011 were identified from the Utah Cancer Registry and linked to pedigrees from the Utah Population Database. Age- and gender-matched BTC-free controls were selected to form the comparison group for determining BTC risk in relatives using Cox regression analysis. Results: Of the 1302 index patients diagnosed with BTC, 550 (42.2 \%) were located in the gallbladder and 752 (57.8 \%) were cholangiocarcinomas. There was no elevated risk of BTC (all subsites combined) in FDRs (HR 0.94, 95 \% CI 0.29–3.0), SDRs (HR 0.25, 95 \% CI 0.06–1.03), and FCs (HR 0.96, 95 \% CI 0.61–1.51) of BTC cases compared to cancer-free controls. Similarly, no increased familial risk of GBC or CC was found in relatives of BTC patients stratified by tumor subsite compared to relatives of controls. Conclusions: Relatives of BTC patients are not at an increased risk of GBC or CC in a statewide population. This suggests that biliary tract cancer risk is not associated with a familial predisposition and may be mitigated more strongly by environmental modifiers.",

keywords = "Biliary tract, Cholangiocarcinoma, Familial, Gallbladder cancer",

author = "Samadder, \{N. Jewel\} and Smith, \{Ken Robert\} and Jathine Wong and Heidi Hanson and Kenneth Boucher and Burt, \{Randall W.\} and Michael Charlton and Byrne, \{Kathryn R.\} and Gallegos-Orozco, \{Juan F.\} and Cathryn Koptiuch and Karen Curtin",

note = "Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media New York.",

year = "2016",

month = dec,

day = "1",

doi = "10.1007/s10620-016-4310-3",

language = "English",

volume = "61",

pages = "3627--3632",

journal = "Digestive Diseases and Sciences",

issn = "0163-2116",

number = "12",

}

TY - JOUR

T1 - Familial Risk of Biliary Tract Cancers

T2 - A Population-Based Study in Utah

AU - Samadder, N. Jewel

AU - Smith, Ken Robert

AU - Wong, Jathine

AU - Hanson, Heidi

AU - Boucher, Kenneth

AU - Burt, Randall W.

AU - Charlton, Michael

AU - Byrne, Kathryn R.

AU - Gallegos-Orozco, Juan F.

AU - Koptiuch, Cathryn

AU - Curtin, Karen

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background and Objectives: Biliary tract cancers (BTC) including, cholangiocarcinoma (CC) and gallbladder cancer (GBC), are rare and highly fatal malignancies. The etiology and inherited susceptibility of both malignancies are poorly understood. We quantified the risk of BTC in first-degree (FDR), second-degree (SDR), and first cousin (FC) relatives of individuals with BTC, stratified by tumor subsite. Methods: BTC diagnosed between 1980 and 2011 were identified from the Utah Cancer Registry and linked to pedigrees from the Utah Population Database. Age- and gender-matched BTC-free controls were selected to form the comparison group for determining BTC risk in relatives using Cox regression analysis. Results: Of the 1302 index patients diagnosed with BTC, 550 (42.2 %) were located in the gallbladder and 752 (57.8 %) were cholangiocarcinomas. There was no elevated risk of BTC (all subsites combined) in FDRs (HR 0.94, 95 % CI 0.29–3.0), SDRs (HR 0.25, 95 % CI 0.06–1.03), and FCs (HR 0.96, 95 % CI 0.61–1.51) of BTC cases compared to cancer-free controls. Similarly, no increased familial risk of GBC or CC was found in relatives of BTC patients stratified by tumor subsite compared to relatives of controls. Conclusions: Relatives of BTC patients are not at an increased risk of GBC or CC in a statewide population. This suggests that biliary tract cancer risk is not associated with a familial predisposition and may be mitigated more strongly by environmental modifiers.

AB - Background and Objectives: Biliary tract cancers (BTC) including, cholangiocarcinoma (CC) and gallbladder cancer (GBC), are rare and highly fatal malignancies. The etiology and inherited susceptibility of both malignancies are poorly understood. We quantified the risk of BTC in first-degree (FDR), second-degree (SDR), and first cousin (FC) relatives of individuals with BTC, stratified by tumor subsite. Methods: BTC diagnosed between 1980 and 2011 were identified from the Utah Cancer Registry and linked to pedigrees from the Utah Population Database. Age- and gender-matched BTC-free controls were selected to form the comparison group for determining BTC risk in relatives using Cox regression analysis. Results: Of the 1302 index patients diagnosed with BTC, 550 (42.2 %) were located in the gallbladder and 752 (57.8 %) were cholangiocarcinomas. There was no elevated risk of BTC (all subsites combined) in FDRs (HR 0.94, 95 % CI 0.29–3.0), SDRs (HR 0.25, 95 % CI 0.06–1.03), and FCs (HR 0.96, 95 % CI 0.61–1.51) of BTC cases compared to cancer-free controls. Similarly, no increased familial risk of GBC or CC was found in relatives of BTC patients stratified by tumor subsite compared to relatives of controls. Conclusions: Relatives of BTC patients are not at an increased risk of GBC or CC in a statewide population. This suggests that biliary tract cancer risk is not associated with a familial predisposition and may be mitigated more strongly by environmental modifiers.

KW - Biliary tract

KW - Cholangiocarcinoma

KW - Familial

KW - Gallbladder cancer

UR - https://www.scopus.com/pages/publications/84988661367

U2 - 10.1007/s10620-016-4310-3

DO - 10.1007/s10620-016-4310-3

M3 - Article

C2 - 27655103

AN - SCOPUS:84988661367

SN - 0163-2116

VL - 61

SP - 3627

EP - 3632

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

IS - 12

ER -

Familial Risk of Biliary Tract Cancers: A Population-Based Study in Utah

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