Facile synthetic route for surface-functionalized magnetic nanoparticles: Cell labeling and magnetic resonance imaging studies

Hyun Jung Chung; Haeshin Lee; Ki Hyun Bae; Yuhan Lee; Jongnam Park; Seung Woo Cho; Jin Young Hwang; Hyunwook Park; Robert Langer; Daniel Anderson; Tae Gwan Park

doi:10.1021/nn201198f

Facile synthetic route for surface-functionalized magnetic nanoparticles: Cell labeling and magnetic resonance imaging studies

Hyun Jung Chung, Haeshin Lee, Ki Hyun Bae, Yuhan Lee, Jongnam Park, Seung Woo Cho, Jin Young Hwang, Hyunwook Park, Robert Langer, Daniel Anderson, Tae Gwan Park

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Currently available methods to stably disperse iron oxide nanoparticles (IONPs) in aqueous solution need to be improved due to potential aggregation, reduction of superparamagnetism, and the use of toxic reagents. Herein, we present a facile strategy for aqueous transfer and dispersion of organic-synthesized IONPs using only polyethylene glycol (PEG), a biocompatible polymer. A library of PEG derivatives was screened, and it was determined that amine-functionalized six-armed PEG, 6(PEG-NH₂), was the most effective dispersion agent. The 6(PEG-NH₂)-modified IONPs (IONP-6PEG) were stable after extensive washing, exhibited high superparamagnetism, and could be used as a platform material for secondary surface functionalization with bioactive polymers. IONP-6PEG biofunctionalized with hyaluronic acid (IONP-6PEG-HA) was shown to specifically label mesenchymal stem cells and demonstrate MR contrast potential with high r₂ relaxivity (442.7 s^-1mM^-1) compared to the commercially available Feridex (182.1 s^-1mM^-1).

Original language	English
Pages (from-to)	4329-4336
Number of pages	8
Journal	ACS Nano
Volume	5
Issue number	6
DOIs	https://doi.org/10.1021/nn201198f
State	Published - Jun 28 2011
Externally published	Yes

Keywords

MRI
PEG
dispersion
iron oxide nanoparticles
surface functionalization

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10.1021/nn201198f

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title = "Facile synthetic route for surface-functionalized magnetic nanoparticles: Cell labeling and magnetic resonance imaging studies",

abstract = "Currently available methods to stably disperse iron oxide nanoparticles (IONPs) in aqueous solution need to be improved due to potential aggregation, reduction of superparamagnetism, and the use of toxic reagents. Herein, we present a facile strategy for aqueous transfer and dispersion of organic-synthesized IONPs using only polyethylene glycol (PEG), a biocompatible polymer. A library of PEG derivatives was screened, and it was determined that amine-functionalized six-armed PEG, 6(PEG-NH2), was the most effective dispersion agent. The 6(PEG-NH2)-modified IONPs (IONP-6PEG) were stable after extensive washing, exhibited high superparamagnetism, and could be used as a platform material for secondary surface functionalization with bioactive polymers. IONP-6PEG biofunctionalized with hyaluronic acid (IONP-6PEG-HA) was shown to specifically label mesenchymal stem cells and demonstrate MR contrast potential with high r2 relaxivity (442.7 s-1mM-1) compared to the commercially available Feridex (182.1 s-1mM-1).",

keywords = "MRI, PEG, dispersion, iron oxide nanoparticles, surface functionalization",

author = "Chung, {Hyun Jung} and Haeshin Lee and Bae, {Ki Hyun} and Yuhan Lee and Jongnam Park and Cho, {Seung Woo} and Hwang, {Jin Young} and Hyunwook Park and Robert Langer and Daniel Anderson and Park, {Tae Gwan}",

year = "2011",

month = jun,

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doi = "10.1021/nn201198f",

language = "English",

volume = "5",

pages = "4329--4336",

journal = "ACS Nano",

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T1 - Facile synthetic route for surface-functionalized magnetic nanoparticles

T2 - Cell labeling and magnetic resonance imaging studies

AU - Chung, Hyun Jung

AU - Lee, Haeshin

AU - Bae, Ki Hyun

AU - Lee, Yuhan

AU - Park, Jongnam

AU - Cho, Seung Woo

AU - Hwang, Jin Young

AU - Park, Hyunwook

AU - Langer, Robert

AU - Anderson, Daniel

AU - Park, Tae Gwan

PY - 2011/6/28

Y1 - 2011/6/28

N2 - Currently available methods to stably disperse iron oxide nanoparticles (IONPs) in aqueous solution need to be improved due to potential aggregation, reduction of superparamagnetism, and the use of toxic reagents. Herein, we present a facile strategy for aqueous transfer and dispersion of organic-synthesized IONPs using only polyethylene glycol (PEG), a biocompatible polymer. A library of PEG derivatives was screened, and it was determined that amine-functionalized six-armed PEG, 6(PEG-NH2), was the most effective dispersion agent. The 6(PEG-NH2)-modified IONPs (IONP-6PEG) were stable after extensive washing, exhibited high superparamagnetism, and could be used as a platform material for secondary surface functionalization with bioactive polymers. IONP-6PEG biofunctionalized with hyaluronic acid (IONP-6PEG-HA) was shown to specifically label mesenchymal stem cells and demonstrate MR contrast potential with high r2 relaxivity (442.7 s-1mM-1) compared to the commercially available Feridex (182.1 s-1mM-1).

AB - Currently available methods to stably disperse iron oxide nanoparticles (IONPs) in aqueous solution need to be improved due to potential aggregation, reduction of superparamagnetism, and the use of toxic reagents. Herein, we present a facile strategy for aqueous transfer and dispersion of organic-synthesized IONPs using only polyethylene glycol (PEG), a biocompatible polymer. A library of PEG derivatives was screened, and it was determined that amine-functionalized six-armed PEG, 6(PEG-NH2), was the most effective dispersion agent. The 6(PEG-NH2)-modified IONPs (IONP-6PEG) were stable after extensive washing, exhibited high superparamagnetism, and could be used as a platform material for secondary surface functionalization with bioactive polymers. IONP-6PEG biofunctionalized with hyaluronic acid (IONP-6PEG-HA) was shown to specifically label mesenchymal stem cells and demonstrate MR contrast potential with high r2 relaxivity (442.7 s-1mM-1) compared to the commercially available Feridex (182.1 s-1mM-1).

KW - MRI

KW - PEG

KW - dispersion

KW - iron oxide nanoparticles

KW - surface functionalization

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DO - 10.1021/nn201198f

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JO - ACS Nano

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Facile synthetic route for surface-functionalized magnetic nanoparticles: Cell labeling and magnetic resonance imaging studies

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