Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid

Mitra S. Ganewatta; Md Anisur Rahman; Louis Mercado; Tinom Shokfai; Alan W. Decho; Theresa M. Reineke; Chuanbing Tang

doi:10.1016/j.bioactmat.2018.02.001

Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid

Mitra S. Ganewatta, Md Anisur Rahman, Louis Mercado, Tinom Shokfai, Alan W. Decho, Theresa M. Reineke, Chuanbing Tang

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Bacterial infections have become a global issue that requires urgent attention, particularly regarding to emergence of multidrug resistant bacteria. We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain. Interestingly, by choosing appropriate monomers, these cationic polymers can form core-shell micelles. These polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial species. It is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial activities. Cytotoxicity assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers.

Original language	English
Pages (from-to)	186-193
Number of pages	8
Journal	Bioactive Materials
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.bioactmat.2018.02.001
State	Published - Jun 2018
Externally published	Yes

Keywords

Antimicrobial polymers
Bile acid
Facial amphiphilicity
Lithocholic acid
Polyionene
Quaternary ammonium

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10.1016/j.bioactmat.2018.02.001

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title = "Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid",

abstract = "Bacterial infections have become a global issue that requires urgent attention, particularly regarding to emergence of multidrug resistant bacteria. We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain. Interestingly, by choosing appropriate monomers, these cationic polymers can form core-shell micelles. These polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial species. It is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial activities. Cytotoxicity assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers.",

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doi = "10.1016/j.bioactmat.2018.02.001",

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T1 - Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid

AU - Ganewatta, Mitra S.

AU - Rahman, Md Anisur

AU - Mercado, Louis

AU - Shokfai, Tinom

AU - Decho, Alan W.

AU - Reineke, Theresa M.

AU - Tang, Chuanbing

PY - 2018/6

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AB - Bacterial infections have become a global issue that requires urgent attention, particularly regarding to emergence of multidrug resistant bacteria. We developed quaternary amine-containing antimicrobial poly(bile acid)s that contain a hydrophobic core of lithocholic acid in the main-chain. Interestingly, by choosing appropriate monomers, these cationic polymers can form core-shell micelles. These polymers exhibited biocidal activity against both Gram-positive and Gram-negative bacterial species. It is demonstrated that the micelles can deliver hydrophobic antibiotics that functionally have dual antimicrobial activities. Cytotoxicity assays against HeLa cells showed dosage-dependent toxicity for polymers with longer linkers.

KW - Antimicrobial polymers

KW - Bile acid

KW - Facial amphiphilicity

KW - Lithocholic acid

KW - Polyionene

KW - Quaternary ammonium

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Facially amphiphilic polyionene biocidal polymers derived from lithocholic acid

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