Abstract
A battery-powered, controlled-current, two-electrode electrochemical cell containing a porous flow-through working electrode with high surface area and multiple auxiliary electrodes with small total surface area was incorporated into the electrospray emitter circuit to control the electrochemical reactions of analytes in the electrospray emitter. This cell system provided the ability to control the extent of analyte oxidation in positive ion mode in the electrospray emitter by simply setting the magnitude and polarity of the current at the working electrode. In addition, this cell provided the ability to effectively reduce analytes in positive ion mode and oxidize analytes in negative ion mode. The small size, economics, and ease of use of such a battery-powered controlled-current emitter cell was demonstrated by powering a single resistor and switch circuit with a small-size, 3 V watch battery, all of which might be incorporated on the emitter cell.
| Original language | English |
|---|---|
| Pages (from-to) | 953-961 |
| Number of pages | 9 |
| Journal | Journal of the American Society for Mass Spectrometry |
| Volume | 17 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2006 |
Funding
ES-MS instrumentation and electrochemical cell and associated components, respectively, were provided through a Cooperative Research and Development Agreement with MDS SCIEX and ESA Biosciences, Inc. (CRADA no. ORNL02-0662). VK acknowledges an ORNL appointment through the ORNL Postdoctoral Research Associates Program. The work carried out at ORNL was supported by the Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences, United States Department of Energy under contract no. DE-AC05-00OR22725 with ORNL, managed and operated by UT-Battelle, LLC.
| Funders | Funder number |
|---|---|
| Office of Basic Energy Sciences | |
| United States Department of Energy | |
| Oak Ridge National Laboratory | |
| Chemical Sciences, Geosciences, and Biosciences Division |