Evaluation of 186WS2target material for production of high specific activity 186Re via proton irradiation: Separation, radiolabeling and recovery/recycling

Anster Charles; Firouzeh Najafi Khosrashahi; Li Ma; Chathurya Munindradasa; Rebecca Hoerres; John D. Lydon; Steven P. Kelley; James Guthrie; David Rotsch; Dmitri Medvedev; Cathy S. Cutler; Yawen Li; D. Scott Wilbur; Heather M. Hennkens; Silvia S. Jurisson

doi:10.1515/ract-2021-1138

Evaluation of ¹⁸⁶WS₂target material for production of high specific activity ¹⁸⁶Re via proton irradiation: Separation, radiolabeling and recovery/recycling

Anster Charles
, Firouzeh Najafi Khosrashahi
, Li Ma
, Chathurya Munindradasa
, Rebecca Hoerres
, John D. Lydon
, Steven P. Kelley
, James Guthrie
, David Rotsch
, Dmitri Medvedev
, Cathy S. Cutler
, Yawen Li
, D. Scott Wilbur
, Heather M. Hennkens
, Silvia S. Jurisson

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Enriched tungsten disulfide (186WS2) was evaluated at increasing proton beam currents (20-50 μA) and times (up to 4 h) on a GE PETtrace cyclotron for production of high specific activity (HSA) 186Re. The HSA 186Re was separated from the irradiated target as [186Re][ReO4]- by a liquid-liquid extraction method and radiolabeled with a new N2S2 ligand (222-MAMA-N-ethylpropionate). The enriched 186W was recovered from the extraction process, analyzed for purity and enrichment, and converted back to the disulfide (186WS2). The results demonstrate that the 186WS2 is an easily pressed target material that can withstand relatively high currents and can be readily recovered and recycled. The 186Re produced was isolated in high specific activity and readily formed the radiotracers [186Re][ReO(222-MAMA-N-ethylpropionate)] and [186Re][Re(CO)3(OH2)3] +.

Original language	English
Pages (from-to)	739-749
Number of pages	11
Journal	Radiochimica Acta
Volume	110
Issue number	6-9
DOIs	https://doi.org/10.1515/ract-2021-1138
State	Published - Jun 1 2022
Externally published	Yes

Funding

Research funding: The authors gratefully acknowledge support from the U.S. Department of Energy Isotope Program, managed by the Office of Science for Nuclear Physics under grant DE-SC0018662 (SSJ). This work was supported in part by University of Missouri (MU) Tier 2 funds (HMH/SSJ) and MU Life Sciences Fellowship (AC).

Keywords

NSligand (222-MAMA-N-ethylpropionate)
ReO(222-MAMA-N-ethylpropionate)
W(p,n)Re
high specific activity (HSA) Re
tungsten disulfide (WS)

Access to Document

10.1515/ract-2021-1138

Cite this

Charles, A., Khosrashahi, F. N., Ma, L., Munindradasa, C., Hoerres, R., Lydon, J. D., Kelley, S. P., Guthrie, J., Rotsch, D., Medvedev, D., Cutler, C. S., Li, Y., Wilbur, D. S., Hennkens, H. M., & Jurisson, S. S. (2022). Evaluation of ¹⁸⁶WS₂target material for production of high specific activity ¹⁸⁶Re via proton irradiation: Separation, radiolabeling and recovery/recycling. Radiochimica Acta, 110(6-9), 739-749. https://doi.org/10.1515/ract-2021-1138

@article{338b614a4f28426b8c9ac8698e13b190,

title = "Evaluation of 186WS2target material for production of high specific activity 186Re via proton irradiation: Separation, radiolabeling and recovery/recycling",

abstract = "Enriched tungsten disulfide (186WS2) was evaluated at increasing proton beam currents (20-50 μA) and times (up to 4 h) on a GE PETtrace cyclotron for production of high specific activity (HSA) 186Re. The HSA 186Re was separated from the irradiated target as [186Re][ReO4]- by a liquid-liquid extraction method and radiolabeled with a new N2S2 ligand (222-MAMA-N-ethylpropionate). The enriched 186W was recovered from the extraction process, analyzed for purity and enrichment, and converted back to the disulfide (186WS2). The results demonstrate that the 186WS2 is an easily pressed target material that can withstand relatively high currents and can be readily recovered and recycled. The 186Re produced was isolated in high specific activity and readily formed the radiotracers [186Re][ReO(222-MAMA-N-ethylpropionate)] and [186Re][Re(CO)3(OH2)3] +.",

keywords = "NSligand (222-MAMA-N-ethylpropionate), ReO(222-MAMA-N-ethylpropionate), W(p,n)Re, high specific activity (HSA) Re, tungsten disulfide (WS)",

author = "Anster Charles and Khosrashahi, \{Firouzeh Najafi\} and Li Ma and Chathurya Munindradasa and Rebecca Hoerres and Lydon, \{John D.\} and Kelley, \{Steven P.\} and James Guthrie and David Rotsch and Dmitri Medvedev and Cutler, \{Cathy S.\} and Yawen Li and Wilbur, \{D. Scott\} and Hennkens, \{Heather M.\} and Jurisson, \{Silvia S.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Walter de Gruyter GmbH, Berlin/Boston.",

year = "2022",

month = jun,

day = "1",

doi = "10.1515/ract-2021-1138",

language = "English",

volume = "110",

pages = "739--749",

journal = "Radiochimica Acta",

issn = "0033-8230",

publisher = "De Gruyter",

number = "6-9",

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Charles, A, Khosrashahi, FN, Ma, L, Munindradasa, C, Hoerres, R, Lydon, JD, Kelley, SP, Guthrie, J, Rotsch, D, Medvedev, D, Cutler, CS, Li, Y, Wilbur, DS, Hennkens, HM & Jurisson, SS 2022, 'Evaluation of ¹⁸⁶WS₂target material for production of high specific activity ¹⁸⁶Re via proton irradiation: Separation, radiolabeling and recovery/recycling', Radiochimica Acta, vol. 110, no. 6-9, pp. 739-749. https://doi.org/10.1515/ract-2021-1138

TY - JOUR

T1 - Evaluation of 186WS2target material for production of high specific activity 186Re via proton irradiation

T2 - Separation, radiolabeling and recovery/recycling

AU - Charles, Anster

AU - Khosrashahi, Firouzeh Najafi

AU - Ma, Li

AU - Munindradasa, Chathurya

AU - Hoerres, Rebecca

AU - Lydon, John D.

AU - Kelley, Steven P.

AU - Guthrie, James

AU - Rotsch, David

AU - Medvedev, Dmitri

AU - Cutler, Cathy S.

AU - Li, Yawen

AU - Wilbur, D. Scott

AU - Hennkens, Heather M.

AU - Jurisson, Silvia S.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Enriched tungsten disulfide (186WS2) was evaluated at increasing proton beam currents (20-50 μA) and times (up to 4 h) on a GE PETtrace cyclotron for production of high specific activity (HSA) 186Re. The HSA 186Re was separated from the irradiated target as [186Re][ReO4]- by a liquid-liquid extraction method and radiolabeled with a new N2S2 ligand (222-MAMA-N-ethylpropionate). The enriched 186W was recovered from the extraction process, analyzed for purity and enrichment, and converted back to the disulfide (186WS2). The results demonstrate that the 186WS2 is an easily pressed target material that can withstand relatively high currents and can be readily recovered and recycled. The 186Re produced was isolated in high specific activity and readily formed the radiotracers [186Re][ReO(222-MAMA-N-ethylpropionate)] and [186Re][Re(CO)3(OH2)3] +.

AB - Enriched tungsten disulfide (186WS2) was evaluated at increasing proton beam currents (20-50 μA) and times (up to 4 h) on a GE PETtrace cyclotron for production of high specific activity (HSA) 186Re. The HSA 186Re was separated from the irradiated target as [186Re][ReO4]- by a liquid-liquid extraction method and radiolabeled with a new N2S2 ligand (222-MAMA-N-ethylpropionate). The enriched 186W was recovered from the extraction process, analyzed for purity and enrichment, and converted back to the disulfide (186WS2). The results demonstrate that the 186WS2 is an easily pressed target material that can withstand relatively high currents and can be readily recovered and recycled. The 186Re produced was isolated in high specific activity and readily formed the radiotracers [186Re][ReO(222-MAMA-N-ethylpropionate)] and [186Re][Re(CO)3(OH2)3] +.

KW - NSligand (222-MAMA-N-ethylpropionate)

KW - ReO(222-MAMA-N-ethylpropionate)

KW - W(p,n)Re

KW - high specific activity (HSA) Re

KW - tungsten disulfide (WS)

UR - https://www.scopus.com/pages/publications/85129252330

U2 - 10.1515/ract-2021-1138

DO - 10.1515/ract-2021-1138

M3 - Article

AN - SCOPUS:85129252330

SN - 0033-8230

VL - 110

SP - 739

EP - 749

JO - Radiochimica Acta

JF - Radiochimica Acta

IS - 6-9

ER -