Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer

Jaewang Lee; Ji Hyeon You; Min Su Kim; Jong Lyel Roh

doi:10.1016/j.redox.2020.101697

Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer

Jaewang Lee, Ji Hyeon You, Min Su Kim, Jong Lyel Roh

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

Condensed Abstract: Expression of epithelial-mesenchymal transition (EMT) markers was closely related to susceptibility to ferroptosis inducers. Epigenetic reprogramming of EMT to gain a mesenchymal phenotype, such as SIRT1 activation or miR-200 family inhibition, promoted ferroptosis in head and neck cancer cells retaining relatively high epithelial traits and low sensitivity to ferroptosis inducers.

Original language	English
Article number	101697
Journal	Redox Biology
Volume	37
DOIs	https://doi.org/10.1016/j.redox.2020.101697
State	Published - Oct 2020
Externally published	Yes

Funding

This study was supported by the National Research Foundation of Korea (NRF) grant, funded by the Ministry of Science and ICT (MSIT) , The Government of Korea (No. 2019R1A2C2002259 ).

Funders	Funder number
Ministry of Science, ICT and Future Planning	2019R1A2C2002259
National Research Foundation of Korea

Keywords

E-cadherin
Epigenetic reprogramming
Epithelial-mesenchymal transition
Ferroptosis
ZEB1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.redox.2020.101697

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title = "Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer",

abstract = "Condensed Abstract: Expression of epithelial-mesenchymal transition (EMT) markers was closely related to susceptibility to ferroptosis inducers. Epigenetic reprogramming of EMT to gain a mesenchymal phenotype, such as SIRT1 activation or miR-200 family inhibition, promoted ferroptosis in head and neck cancer cells retaining relatively high epithelial traits and low sensitivity to ferroptosis inducers.",

keywords = "E-cadherin, Epigenetic reprogramming, Epithelial-mesenchymal transition, Ferroptosis, ZEB1",

author = "Jaewang Lee and You, {Ji Hyeon} and Kim, {Min Su} and Roh, {Jong Lyel}",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = oct,

doi = "10.1016/j.redox.2020.101697",

language = "English",

volume = "37",

journal = "Redox Biology",

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T1 - Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer

AU - Lee, Jaewang

AU - You, Ji Hyeon

AU - Kim, Min Su

AU - Roh, Jong Lyel

PY - 2020/10

Y1 - 2020/10

N2 - Condensed Abstract: Expression of epithelial-mesenchymal transition (EMT) markers was closely related to susceptibility to ferroptosis inducers. Epigenetic reprogramming of EMT to gain a mesenchymal phenotype, such as SIRT1 activation or miR-200 family inhibition, promoted ferroptosis in head and neck cancer cells retaining relatively high epithelial traits and low sensitivity to ferroptosis inducers.

AB - Condensed Abstract: Expression of epithelial-mesenchymal transition (EMT) markers was closely related to susceptibility to ferroptosis inducers. Epigenetic reprogramming of EMT to gain a mesenchymal phenotype, such as SIRT1 activation or miR-200 family inhibition, promoted ferroptosis in head and neck cancer cells retaining relatively high epithelial traits and low sensitivity to ferroptosis inducers.

KW - E-cadherin

KW - Epigenetic reprogramming

KW - Epithelial-mesenchymal transition

KW - Ferroptosis

KW - ZEB1

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DO - 10.1016/j.redox.2020.101697

M3 - Article

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SN - 2213-2317

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JO - Redox Biology

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ER -

Epigenetic reprogramming of epithelial-mesenchymal transition promotes ferroptosis of head and neck cancer

Abstract

Funding

Keywords

UN SDGs

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