Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy

Murillo L. Martins; Andrea Orecchini; Luis Aguilera; Juergen Eckert; Jan Embs; Aleksander Matic; Margarida J. Saeki; Heloisa N. Bordallo

doi:10.1051/epjconf/20158302011

Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy

Murillo L. Martins, Andrea Orecchini, Luis Aguilera, Juergen Eckert, Jan Embs, Aleksander Matic, Margarida J. Saeki, Heloisa N. Bordallo

Research output: Contribution to journal › Conference article › peer-review

6 Scopus citations

Abstract

The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.

Original language	English
Article number	02011
Journal	EPJ Web of Conferences
Volume	83
DOIs	https://doi.org/10.1051/epjconf/20158302011
State	Published - Jan 23 2015
Externally published	Yes
Event	11th International Conference on Quasielastic Neutron Scattering, QENS 2014 and 6th International Workshop on Inelastic Neutron Spectrometers, WINS 2014 - Autrans, France Duration: May 11 2014 → May 16 2014

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title = "Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy",

abstract = "The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.",

author = "Martins, {Murillo L.} and Andrea Orecchini and Luis Aguilera and Juergen Eckert and Jan Embs and Aleksander Matic and Saeki, {Margarida J.} and Bordallo, {Heloisa N.}",

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year = "2015",

month = jan,

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doi = "10.1051/epjconf/20158302011",

language = "English",

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T1 - Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy

AU - Martins, Murillo L.

AU - Orecchini, Andrea

AU - Aguilera, Luis

AU - Eckert, Juergen

AU - Embs, Jan

AU - Matic, Aleksander

AU - Saeki, Margarida J.

AU - Bordallo, Heloisa N.

PY - 2015/1/23

Y1 - 2015/1/23

N2 - The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.

AB - The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.

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U2 - 10.1051/epjconf/20158302011

DO - 10.1051/epjconf/20158302011

M3 - Conference article

AN - SCOPUS:84921745049

SN - 2101-6275

VL - 83

JO - EPJ Web of Conferences

JF - EPJ Web of Conferences

M1 - 02011

T2 - 11th International Conference on Quasielastic Neutron Scattering, QENS 2014 and 6th International Workshop on Inelastic Neutron Spectrometers, WINS 2014

Y2 - 11 May 2014 through 16 May 2014

ER -

Encapsulation of paclitaxel into a bio-nanocomposite. A study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy

Abstract

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