Enantioselective Syntheses of Homopropargylic Alcohols via Asymmetric Allenylboration

Mengzhou Wang; Shahriar Khan; Evangelos Miliordos; Ming Chen

doi:10.1021/acs.orglett.8b01399

Enantioselective Syntheses of Homopropargylic Alcohols via Asymmetric Allenylboration

Mengzhou Wang, Shahriar Khan, Evangelos Miliordos, Ming Chen

Advanced Computing for Chemistry and Mat

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50 Scopus citations

Abstract

A chiral phosphoric acid catalyzed allenylboration reaction is reported. Homopropargyl alcohols with an internal alkyne unit were obtained in good yields with high enantioselectivities under the developed conditions.

Original language	English
Pages (from-to)	3810-3814
Number of pages	5
Journal	Organic Letters
Volume	20
Issue number	13
DOIs	https://doi.org/10.1021/acs.orglett.8b01399
State	Published - Jul 6 2018

Funding

Financial support provided by Auburn University is gratefully acknowledged. We thank the Schneller, the Merner and the Gordon groups at Auburn University for sharing the chemicals, and AllylChem for a generous gift of B2Pin2.

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@article{8a183ab21ec14994889bd0c2969fa003,

title = "Enantioselective Syntheses of Homopropargylic Alcohols via Asymmetric Allenylboration",

abstract = "A chiral phosphoric acid catalyzed allenylboration reaction is reported. Homopropargyl alcohols with an internal alkyne unit were obtained in good yields with high enantioselectivities under the developed conditions.",

author = "Mengzhou Wang and Shahriar Khan and Evangelos Miliordos and Ming Chen",

note = "Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = jul,

day = "6",

doi = "10.1021/acs.orglett.8b01399",

language = "English",

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T1 - Enantioselective Syntheses of Homopropargylic Alcohols via Asymmetric Allenylboration

AU - Wang, Mengzhou

AU - Khan, Shahriar

AU - Miliordos, Evangelos

AU - Chen, Ming

PY - 2018/7/6

Y1 - 2018/7/6

N2 - A chiral phosphoric acid catalyzed allenylboration reaction is reported. Homopropargyl alcohols with an internal alkyne unit were obtained in good yields with high enantioselectivities under the developed conditions.

AB - A chiral phosphoric acid catalyzed allenylboration reaction is reported. Homopropargyl alcohols with an internal alkyne unit were obtained in good yields with high enantioselectivities under the developed conditions.

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DO - 10.1021/acs.orglett.8b01399

M3 - Article

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EP - 3814

JO - Organic Letters

JF - Organic Letters

IS - 13

ER -

Enantioselective Syntheses of Homopropargylic Alcohols via Asymmetric Allenylboration

Abstract

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