TY - JOUR
T1 - Elucidation of methanogenic coenzyme biosyntheses
T2 - From spectroscopy to genomics
AU - Graham, David E.
AU - White, Robert H.
PY - 2002
Y1 - 2002
N2 - Methanogenesis, the anaerobic production of methane from CO2 or simple carbon compounds, requires seven organic coenzymes. This review describes pathways for the biosynthesis of methanofuran, 5,6,7,8-tetrahydromethanopterin, coenzyme F420, coenzyme M (2-mercaptoethanesulfonic acid) and coenzyme B (7-mercaptoheptanoyl-L-threonine phosphate). Spectroscopic evidence for the pathways is reviewed and recent efforts are described to identify and characterize the biosynthetic enzymes from methanogenic archaea. The literature from 1971 to September 2001 is reviewed, and 169 references are cited.
AB - Methanogenesis, the anaerobic production of methane from CO2 or simple carbon compounds, requires seven organic coenzymes. This review describes pathways for the biosynthesis of methanofuran, 5,6,7,8-tetrahydromethanopterin, coenzyme F420, coenzyme M (2-mercaptoethanesulfonic acid) and coenzyme B (7-mercaptoheptanoyl-L-threonine phosphate). Spectroscopic evidence for the pathways is reviewed and recent efforts are described to identify and characterize the biosynthetic enzymes from methanogenic archaea. The literature from 1971 to September 2001 is reviewed, and 169 references are cited.
UR - http://www.scopus.com/inward/record.url?scp=0036005602&partnerID=8YFLogxK
U2 - 10.1039/b103714p
DO - 10.1039/b103714p
M3 - Article
C2 - 12013276
AN - SCOPUS:0036005602
SN - 0265-0568
VL - 19
SP - 133
EP - 147
JO - Natural Product Reports
JF - Natural Product Reports
IS - 2
ER -