Elucidating the coordination chemistry of the radium ion for targeted alpha therapy

Alexander S. Ivanov; Megan E. Simms; Vyacheslav S. Bryantsev; Paul D. Benny; Justin R. Griswold; Laetitia H. Delmau; Nikki A. Thiele

doi:10.1039/d2cc03156f

Elucidating the coordination chemistry of the radium ion for targeted alpha therapy

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20 Scopus citations

Abstract

The coordination chemistry of Ra²⁺ is poorly defined, hampering efforts to design effective chelators for ²²³Ra-based targeted alpha therapy. Here, we report the complexation thermodynamics of Ra²⁺ with the biomedically-relevant chelators DOTA and macropa. Our work reveals the highest affinity chelator to date for Ra²⁺ and advances our understanding of key factors underlying complex stability and selectivity for this underexplored ion.

Original language	English
Pages (from-to)	9938-9941
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	71
DOIs	https://doi.org/10.1039/d2cc03156f
State	Published - Aug 19 2022

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title = "Elucidating the coordination chemistry of the radium ion for targeted alpha therapy",

abstract = "The coordination chemistry of Ra2+ is poorly defined, hampering efforts to design effective chelators for 223Ra-based targeted alpha therapy. Here, we report the complexation thermodynamics of Ra2+ with the biomedically-relevant chelators DOTA and macropa. Our work reveals the highest affinity chelator to date for Ra2+ and advances our understanding of key factors underlying complex stability and selectivity for this underexplored ion.",

author = "Ivanov, \{Alexander S.\} and Simms, \{Megan E.\} and Bryantsev, \{Vyacheslav S.\} and Benny, \{Paul D.\} and Griswold, \{Justin R.\} and Delmau, \{Laetitia H.\} and Thiele, \{Nikki A.\}",

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year = "2022",

month = aug,

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doi = "10.1039/d2cc03156f",

language = "English",

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journal = "Chemical Communications",

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T1 - Elucidating the coordination chemistry of the radium ion for targeted alpha therapy

AU - Ivanov, Alexander S.

AU - Simms, Megan E.

AU - Bryantsev, Vyacheslav S.

AU - Benny, Paul D.

AU - Griswold, Justin R.

AU - Delmau, Laetitia H.

AU - Thiele, Nikki A.

PY - 2022/8/19

Y1 - 2022/8/19

N2 - The coordination chemistry of Ra2+ is poorly defined, hampering efforts to design effective chelators for 223Ra-based targeted alpha therapy. Here, we report the complexation thermodynamics of Ra2+ with the biomedically-relevant chelators DOTA and macropa. Our work reveals the highest affinity chelator to date for Ra2+ and advances our understanding of key factors underlying complex stability and selectivity for this underexplored ion.

AB - The coordination chemistry of Ra2+ is poorly defined, hampering efforts to design effective chelators for 223Ra-based targeted alpha therapy. Here, we report the complexation thermodynamics of Ra2+ with the biomedically-relevant chelators DOTA and macropa. Our work reveals the highest affinity chelator to date for Ra2+ and advances our understanding of key factors underlying complex stability and selectivity for this underexplored ion.

UR - https://www.scopus.com/pages/publications/85136664524

U2 - 10.1039/d2cc03156f

DO - 10.1039/d2cc03156f

M3 - Article

C2 - 35983753

AN - SCOPUS:85136664524

SN - 1359-7345

VL - 58

SP - 9938

EP - 9941

JO - Chemical Communications

JF - Chemical Communications

IS - 71

ER -

Elucidating the coordination chemistry of the radium ion for targeted alpha therapy

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