Elastic phase response of silica nanoparticles buried in soft matter

Laurene Tetard; Ali Passian; Rachel M. Lynch; Brynn H. Voy; Gajendra Shekhawat; Vinayak Dravid; Thomas Thundat

doi:10.1063/1.2987460

Elastic phase response of silica nanoparticles buried in soft matter

Laurene Tetard, Ali Passian, Rachel M. Lynch, Brynn H. Voy, Gajendra Shekhawat, Vinayak Dravid, Thomas Thundat

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Tracking the uptake of nanomaterials by living cells is an important component in assessing both potential toxicity and in designing future materials for use in vivo. We show that the difference in the local elasticity at the site of silica (_SiO2) nanoparticles confined within a macrophage enables functional ultrasonic interactions. By elastically exciting the cell, a phase perturbation caused by the buried _SiO2 nanoparticles was detected and used to map the subsurface populations of nanoparticles. Localization and mapping of stiff chemically synthesized silica nanoparticles within the cellular structures of a macrophage are important in basic as well as applied studies.

Original language	English
Article number	133113
Journal	Applied Physics Letters
Volume	93
Issue number	13
DOIs	https://doi.org/10.1063/1.2987460
State	Published - 2008

Funding

This research was sponsored by DOE-OBER. We are indebted to W. Wang and B. Gu of ORNL for their support and for supplying silica, and D. Glass for help with animal experiments. Research of V.P.D. and G.S. was supported by NSF-NSEC and SRC. We are grateful to V. Castranova at NIOSH for training with the pharyngeal aspiration and BAL techniques. ORNL is managed by UT-Battelle, LLC, for the U.S. Department of Energy under Contract No. DE-AC05-00OR22725.

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Elastic phase response of silica nanoparticles buried in soft matter

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