TY - JOUR
T1 - Elastic and conformational softness of a globular protein
AU - Hong, Liang
AU - Glass, Dennis C.
AU - Nickels, Jonathan D.
AU - Perticaroli, Stefania
AU - Yi, Zheng
AU - Madhusudan, Tyagi
AU - O'Neill, Hugh
AU - Zhang, Qiu
AU - Sokolov, Alexei P.
AU - Smith, Jeremy C.
PY - 2013/1/10
Y1 - 2013/1/10
N2 - Flexibility, or softness, is crucial for protein function and consists of a conformational component, involving jumps between potential wells, and an elastic component, involving fluctuations within the wells. Combining molecular dynamics simulation with incoherent neutron scattering and light scattering measurements on green fluorescent protein, we reveal a relationship between the intrawell fluctuations and elastic moduli of the protein. This finding leads to a simple means of experimentally separating the conformational from the elastic atomic displacements.
AB - Flexibility, or softness, is crucial for protein function and consists of a conformational component, involving jumps between potential wells, and an elastic component, involving fluctuations within the wells. Combining molecular dynamics simulation with incoherent neutron scattering and light scattering measurements on green fluorescent protein, we reveal a relationship between the intrawell fluctuations and elastic moduli of the protein. This finding leads to a simple means of experimentally separating the conformational from the elastic atomic displacements.
UR - http://www.scopus.com/inward/record.url?scp=84872234122&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.110.028104
DO - 10.1103/PhysRevLett.110.028104
M3 - Article
C2 - 23383942
AN - SCOPUS:84872234122
SN - 0031-9007
VL - 110
JO - Physical Review Letters
JF - Physical Review Letters
IS - 2
M1 - 028104
ER -