Efficient LC separations of proteins and peptides for MS analysis

Nathan C. VerBerkmoes; Robert L. Hettich; Theresa L. Savage; Reno Nguyen

Efficient LC separations of proteins and peptides for MS analysis

Nathan C. VerBerkmoes
, Robert L. Hettich
, Theresa L. Savage
, Reno Nguyen

Bioanalytical Mass Spectrometry

Research output: Contribution to journal › Article › peer-review

Abstract

Current proteomics and genomics research has spurred the pharmaceutical and biotechnology industries to keep up with technical demands. There is currently a need for robust liquid-phase separations of complex protein and peptide mixtures. In this study, a VYDAC® capillary LC/MS column was directly compared with another leading commercial column of the same dimensions. It was then used to rapidly identify 2037 proteins from multiple complex peptide mixtures in a robust and high-throughput manner.

Original language	English
Pages (from-to)	14-15
Number of pages	2
Journal	LC-GC North America
Volume	20
Issue number	2 SUPPL.
State	Published - Feb 1 2002

Cite this

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AU - Savage, Theresa L.

AU - Nguyen, Reno

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N2 - Current proteomics and genomics research has spurred the pharmaceutical and biotechnology industries to keep up with technical demands. There is currently a need for robust liquid-phase separations of complex protein and peptide mixtures. In this study, a VYDAC® capillary LC/MS column was directly compared with another leading commercial column of the same dimensions. It was then used to rapidly identify 2037 proteins from multiple complex peptide mixtures in a robust and high-throughput manner.

AB - Current proteomics and genomics research has spurred the pharmaceutical and biotechnology industries to keep up with technical demands. There is currently a need for robust liquid-phase separations of complex protein and peptide mixtures. In this study, a VYDAC® capillary LC/MS column was directly compared with another leading commercial column of the same dimensions. It was then used to rapidly identify 2037 proteins from multiple complex peptide mixtures in a robust and high-throughput manner.

UR - https://www.scopus.com/pages/publications/0036487763

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JO - LC-GC North America

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Efficient LC separations of proteins and peptides for MS analysis

Abstract

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