Efficient iron(iii)-catalyzed three-component coupling reaction of alkynes, CH2Cl2and amines to propargylamines

Jian Gao; Qing Wen Song; Liang Nian He; Zhen Zhen Yang; Xiao Yong Dou

doi:10.1039/c2cc17616e

Efficient iron(iii)-catalyzed three-component coupling reaction of alkynes, CH₂Cl₂and amines to propargylamines

Jian Gao
, Qing Wen Song
, Liang Nian He
, Zhen Zhen Yang
, Xiao Yong Dou

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

An iron(iii)-catalyzed three-component coupling reaction of alkynes, CH₂Cl₂and amines was developed for facile synthesis of propargylamines. Preliminary mechanism investigation using in situ FT-IR reveals that the crucial Fe-acetylide intermediate could be formed through C-H bond activation of alkynes thanks to cooperative effect of FeCl₃and 1,1,3,3-tetramethylguanidine.

Original language	English
Pages (from-to)	2024-2026
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	14
DOIs	https://doi.org/10.1039/c2cc17616e
State	Published - Jan 18 2012
Externally published	Yes

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title = "Efficient iron(iii)-catalyzed three-component coupling reaction of alkynes, CH2Cl2and amines to propargylamines",

abstract = "An iron(iii)-catalyzed three-component coupling reaction of alkynes, CH2Cl2and amines was developed for facile synthesis of propargylamines. Preliminary mechanism investigation using in situ FT-IR reveals that the crucial Fe-acetylide intermediate could be formed through C-H bond activation of alkynes thanks to cooperative effect of FeCl3and 1,1,3,3-tetramethylguanidine.",

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AU - Gao, Jian

AU - Song, Qing Wen

AU - He, Liang Nian

AU - Yang, Zhen Zhen

AU - Dou, Xiao Yong

PY - 2012/1/18

Y1 - 2012/1/18

N2 - An iron(iii)-catalyzed three-component coupling reaction of alkynes, CH2Cl2and amines was developed for facile synthesis of propargylamines. Preliminary mechanism investigation using in situ FT-IR reveals that the crucial Fe-acetylide intermediate could be formed through C-H bond activation of alkynes thanks to cooperative effect of FeCl3and 1,1,3,3-tetramethylguanidine.

AB - An iron(iii)-catalyzed three-component coupling reaction of alkynes, CH2Cl2and amines was developed for facile synthesis of propargylamines. Preliminary mechanism investigation using in situ FT-IR reveals that the crucial Fe-acetylide intermediate could be formed through C-H bond activation of alkynes thanks to cooperative effect of FeCl3and 1,1,3,3-tetramethylguanidine.

UR - https://www.scopus.com/pages/publications/84863011971

U2 - 10.1039/c2cc17616e

DO - 10.1039/c2cc17616e

M3 - Article

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AN - SCOPUS:84863011971

SN - 1359-7345

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JO - Chemical Communications

JF - Chemical Communications

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Efficient iron(iii)-catalyzed three-component coupling reaction of alkynes, CH₂Cl₂and amines to propargylamines

Abstract

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