Efficient iron(iii)-catalyzed three-component coupling reaction of alkynes, CH2Cl2and amines to propargylamines

Jian Gao; Qing Wen Song; Liang Nian He; Zhen Zhen Yang; Xiao Yong Dou

doi:10.1039/c2cc17616e

Efficient iron(iii)-catalyzed three-component coupling reaction of alkynes, CH₂Cl₂and amines to propargylamines

Jian Gao, Qing Wen Song, Liang Nian He, Zhen Zhen Yang, Xiao Yong Dou

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

An iron(iii)-catalyzed three-component coupling reaction of alkynes, CH₂Cl₂and amines was developed for facile synthesis of propargylamines. Preliminary mechanism investigation using in situ FT-IR reveals that the crucial Fe-acetylide intermediate could be formed through C-H bond activation of alkynes thanks to cooperative effect of FeCl₃and 1,1,3,3-tetramethylguanidine.

Original language	English
Pages (from-to)	2024-2026
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	14
DOIs	https://doi.org/10.1039/c2cc17616e
State	Published - Jan 18 2012
Externally published	Yes

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abstract = "An iron(iii)-catalyzed three-component coupling reaction of alkynes, CH2Cl2and amines was developed for facile synthesis of propargylamines. Preliminary mechanism investigation using in situ FT-IR reveals that the crucial Fe-acetylide intermediate could be formed through C-H bond activation of alkynes thanks to cooperative effect of FeCl3and 1,1,3,3-tetramethylguanidine.",

author = "Jian Gao and Song, {Qing Wen} and He, {Liang Nian} and Yang, {Zhen Zhen} and Dou, {Xiao Yong}",

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AU - Gao, Jian

AU - Song, Qing Wen

AU - He, Liang Nian

AU - Yang, Zhen Zhen

AU - Dou, Xiao Yong

PY - 2012/1/18

Y1 - 2012/1/18

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AB - An iron(iii)-catalyzed three-component coupling reaction of alkynes, CH2Cl2and amines was developed for facile synthesis of propargylamines. Preliminary mechanism investigation using in situ FT-IR reveals that the crucial Fe-acetylide intermediate could be formed through C-H bond activation of alkynes thanks to cooperative effect of FeCl3and 1,1,3,3-tetramethylguanidine.

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Efficient iron(iii)-catalyzed three-component coupling reaction of alkynes, CH₂Cl₂and amines to propargylamines

Abstract

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